Russian Journal of BiotherapyRussian Journal of BiotherapyРоссийский биотерапевтический журнал1726-97841726-9792Publishing House ABV Press87410.17650/1726-9784-2017-16-3-14-20REVIEWSОБЗОРЫ ЛИТЕРАТУРЫIron metabolism, ferroptosis and cancerМетаболизм железа, ферроптоз, ракVartanianA. A.ВартанянА. А.
Russian Federation
zhivotov57@mail.ruN.N. Blokhin Russian Cancer Research CenterФГБУ «НМИЦ онкологии им. Н.Н. Блохина» Минздрава России30092017163142010042018https://bioterapevt.abvpress.ru/jour/article/view/874

In 2012 the new, iron-dependent form of cell death - ferroptosis - distinct from apoptosis, autophagy and programmed necrosis at morphological, biochemical, and genetic levels has been described. In this review we will discuss the iron metabolism in physiological and pathological processes in humans, the molecular characteristics of ferroptosis and therapeutic options of cancer patients in the light of new data.

В 2012 г. была описана новая, железозависимая форма клеточной гибели - ферроптоз, отличающаяся по морфологическим, биохимическим и генетическим особенностям от апоптоза, аутофагии и программируемого некроза. В обзоре обсуждаются вопросы метаболизма железа в норме и при злокачественных новообразованиях, молекулярные характеристики ферроптоза и возможности терапии онкологических больных в свете новых данных.

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