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<article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:ali="http://www.niso.org/schemas/ali/1.0/" article-type="other" dtd-version="1.2" xml:lang="en"><front><journal-meta><journal-id journal-id-type="publisher-id">Russian Journal of Biotherapy</journal-id><journal-title-group><journal-title xml:lang="en">Russian Journal of Biotherapy</journal-title><trans-title-group xml:lang="ru"><trans-title>Российский биотерапевтический журнал</trans-title></trans-title-group></journal-title-group><issn publication-format="print">1726-9784</issn><issn publication-format="electronic">1726-9792</issn><publisher><publisher-name xml:lang="en">Publishing House ABV Press</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="publisher-id">871</article-id><article-id pub-id-type="doi">10.17650/1726-9784-2017-16-2-91-96</article-id><article-categories><subj-group subj-group-type="toc-heading" xml:lang="en"><subject>ORIGINAL REPORTS</subject></subj-group><subj-group subj-group-type="toc-heading" xml:lang="ru"><subject>ОРИГИНАЛЬНЫЕ СТАТЬИ</subject></subj-group><subj-group subj-group-type="article-type"><subject></subject></subj-group></article-categories><title-group><article-title xml:lang="en">Analysis of changes in subpopulation of T-regulatory cells CD4+CD25+ in metastatic renal cell carcinoma</article-title><trans-title-group xml:lang="ru"><trans-title>Анализ динамики субпопуляции Т-регуляторных клеток CD4+CD25+ при метастатическом почечно-клеточном раке</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Sayapina</surname><given-names>M. S.</given-names></name><name xml:lang="ru"><surname>Саяпина</surname><given-names>М. С.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><email>maria.sayapina@mail.ru</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Borunova</surname><given-names>A. A.</given-names></name><name xml:lang="ru"><surname>Борунова</surname><given-names>А. А.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Zabotina</surname><given-names>T. N.</given-names></name><name xml:lang="ru"><surname>Заботина</surname><given-names>Т. Н.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Nosov</surname><given-names>D. A.</given-names></name><name xml:lang="ru"><surname>Носов</surname><given-names>Д. А.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><xref ref-type="aff" rid="aff2"/></contrib></contrib-group><aff-alternatives id="aff1"><aff><institution xml:lang="en">N.N. Blokhin Russian Cancer Research Center, Ministry of Health of Russia</institution></aff><aff><institution xml:lang="ru">ФГБУ «РОНЦ им. Н.Н. Блохина» Минздрава России</institution></aff></aff-alternatives><aff-alternatives id="aff2"><aff><institution xml:lang="en">Central Clinical Hospital, Administration of President of Russia</institution></aff><aff><institution xml:lang="ru">ФГБУ «Центральная клиническая больница с поликлиникой» Управления делами Президента РФ</institution></aff></aff-alternatives><pub-date date-type="pub" iso-8601-date="2017-06-30" publication-format="electronic"><day>30</day><month>06</month><year>2017</year></pub-date><volume>16</volume><issue>2</issue><fpage>91</fpage><lpage>96</lpage><history><date date-type="received" iso-8601-date="2018-04-10"><day>10</day><month>04</month><year>2018</year></date></history><permissions/><self-uri xlink:href="https://bioterapevt.abvpress.ru/jour/article/view/871">https://bioterapevt.abvpress.ru/jour/article/view/871</self-uri><abstract xml:lang="en"><p/></abstract><trans-abstract xml:lang="ru"><p/></trans-abstract><kwd-group xml:lang="ru"><kwd>Т-регуляторные клетки</kwd><kwd>интерферон альфа</kwd><kwd>метастатический почечно-клеточый рак</kwd><kwd>T-regulatory cells CD4<sup>+</sup>CD25<sup>+</sup></kwd><kwd>interferon alpha</kwd><kwd>metastatic renal cell carcinoma</kwd></kwd-group></article-meta></front><body></body><back><ref-list><ref id="B1"><label>1.</label><mixed-citation>Sakaguchi S. 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