Russian Journal of BiotherapyRussian Journal of BiotherapyРоссийский биотерапевтический журнал1726-97841726-9792Publishing House ABV Press85310.17650/1726-9784-2017-16-1-38-46ORIGINAL REPORTSОРИГИНАЛЬНЫЕ СТАТЬИPROGNOSTIC FACTORS OF THE EFFICACY OF ARANOZA-BAZED THERAPY IN NEUROENDOCRINE NEOPLASMSФАКТОРЫ ПРОГНОЗА ЭФФЕКТИВНОСТИ ТЕРАПИИ НЕЙРОЭНДОКРИННЫХ НОВООБРАЗОВАНИЙ РЕЖИМАМИ НА ОСНОВЕ АРАНОЗЫPolozkovaS. A.ПолозковаСветлана Александровна
Russian Federation
elevana@list.ruGorbunovaV. A.ГорбуноваВ. А.
Russian Federation
DelektorskayaV. V.ДелекторскаяВ. В.
Russian Federation
OrelN. F.ОрелН. Ф.
Russian Federation
KozlovN. N.КозловН. Н.
Russian Federation
KuzminovA. E.КузьминовА. Е.
Russian Federation
MarkovichA. A.МарковичА. А.
Russian Federation
OdintsovaA. S.ОдинцоваА. С.
Russian Federation
EmelyanovaG. S.ЕмельяноваГ. С.
Russian Federation
N.N. Blokhin Russian Cancer Research Center, Ministry of Health of RussiaФГБУ«Российский онкологический научный центр им. Н.Н. Блохина» Минздрава РоссииRussian Medical Academy of Continuous Education, Ministry of Health of RussiаФГБОУ ДПО «Российская медицинская академия непрерывного профессионального образования» Минздрава РоссииA.I. Evdokimov Moscow State Medical and Dental University, Ministry of Health of RussiaГБОУ ВПО «Московский государственный медико-стоматологический университет им. А.И. Евдокимова» Минздрава России30032017161384610042018https://bioterapevt.abvpress.ru/jour/article/view/853

Introduction. In patients with neuroendocrine neoplasms it is necessary to search for new prognostic factors to identify a subgroup of patients who will benefit from drug treatment. Aim. The aim of the study was an optimization of Aranoza-based therapy in patients with neuroendocrine neoplasms by using both morphological and clinical factors as predictors of the treatment efficacy. Materials and methods. A total of 122 patients were enrolled and assessed for radiological response (RECIST 1.0) and progression-free survival. Results. Aranoza and its combinations had similar efficacy. The localization of metastases only in the liver, less than 3 metastatic zones, more than 6 courses of Aranoza-bazed chemotherapy, well-differentiated tumors, absence of doses reduction of Aranoza and temozolomide in anamnesis were predictors of the disease control rate. Progression-free survival was higher in patients with disease control rate (objective response + stabilization more than 6 months), Ki-67 < 20 %, well-differentiated tumors, more than 6 courses of Arano-za-based chemotherapy, objective biochemical response, less than 3 metastatic zones and absence of O6-alkylguanine-DNA alkyl-transferase expression. Conclusion. Future analysis of prognostic factors in patients treated with alkylating agents is needed.

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