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<article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:ali="http://www.niso.org/schemas/ali/1.0/" article-type="other" dtd-version="1.2" xml:lang="en"><front><journal-meta><journal-id journal-id-type="publisher-id">Russian Journal of Biotherapy</journal-id><journal-title-group><journal-title xml:lang="en">Russian Journal of Biotherapy</journal-title><trans-title-group xml:lang="ru"><trans-title>Российский биотерапевтический журнал</trans-title></trans-title-group></journal-title-group><issn publication-format="print">1726-9784</issn><issn publication-format="electronic">1726-9792</issn><publisher><publisher-name xml:lang="en">Publishing House ABV Press</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="publisher-id">850</article-id><article-id pub-id-type="doi">10.17650/1726-9784-2017-16-1-12-23</article-id><article-categories><subj-group subj-group-type="toc-heading" xml:lang="en"><subject>REVIEWS</subject></subj-group><subj-group subj-group-type="toc-heading" xml:lang="ru"><subject>ОБЗОРЫ ЛИТЕРАТУРЫ</subject></subj-group><subj-group subj-group-type="article-type"><subject></subject></subj-group></article-categories><title-group><article-title xml:lang="en">IMPACT OF TUMOR-DERIVED FACTORS ON DENDRITIC CELLS IN CANCER</article-title><trans-title-group xml:lang="ru"><trans-title>ВЛИЯНИЕ СЕКРЕТИРУЕМЫХ ОПУХОЛЬЮ ВЕЩЕСТВ НА ДЕНДРИТНЫЕ КЛЕТКИ ПРИ РАКЕ</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Keskinov</surname><given-names>A. A.</given-names></name><name xml:lang="ru"><surname>Кескинов</surname><given-names>Антон Артурович</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><email>a.keskinov@yahoo.com</email><xref ref-type="aff" rid="aff1"/><xref ref-type="aff" rid="aff2"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Shurin</surname><given-names>M. R.</given-names></name><name xml:lang="ru"><surname>Щурин</surname><given-names>М. Р.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><xref ref-type="aff" rid="aff2"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Bukhman</surname><given-names>V. M.</given-names></name><name xml:lang="ru"><surname>Бухман</surname><given-names>В. М.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Shprakh</surname><given-names>Z. S.</given-names></name><name xml:lang="ru"><surname>Шпрах</surname><given-names>З. С.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><xref ref-type="aff" rid="aff1"/></contrib></contrib-group><aff-alternatives id="aff1"><aff><institution xml:lang="en">N.N. Blokhin Russian Cancer Research Center, Ministry of Health of Russia</institution></aff><aff><institution xml:lang="ru">ФГБУ «Российский онкологический научный центр им. Н.Н. Блохина» Минздрава России</institution></aff></aff-alternatives><aff-alternatives id="aff2"><aff><institution xml:lang="en">University of Pittsburgh</institution></aff><aff><institution xml:lang="ru">Университет г. Питтсбург</institution></aff></aff-alternatives><pub-date date-type="pub" iso-8601-date="2017-03-30" publication-format="electronic"><day>30</day><month>03</month><year>2017</year></pub-date><volume>16</volume><issue>1</issue><fpage>12</fpage><lpage>23</lpage><history><date date-type="received" iso-8601-date="2018-04-10"><day>10</day><month>04</month><year>2018</year></date></history><permissions/><self-uri xlink:href="https://bioterapevt.abvpress.ru/jour/article/view/850">https://bioterapevt.abvpress.ru/jour/article/view/850</self-uri><abstract xml:lang="en"><p>Dendritic cells play key role during tumorigenesis and immune response to it. They are able to uptake and present antigens to T cells, resulting in specific T cell mediated immune response. Furthermore, interaction between dendritic cells and other types of immune cells may boost cell-mediated and humoral immune response to cancer. Contrary to that, numerous tumor-derived factors may attract dendritic cells to neoplastic sites, causing impairment of their maturation, differentiation, and functional activity, resulting in deficiency of anti-tumor immune response or dendritic cell-mediated tolerance. Various factors within tumor microenvironment may either stimulate or inhibit dendritic cells and therefore need to be determined for improving efficacy of biotherapy utilizing dendritic cells. Meanwhile, recovery of dendritic cells functions in cancer patients remains one of primary aims for cancer immunotherapy. This review outlines main types of tumor-derived factors and their impact on dendritic cells in cancer.</p></abstract><trans-abstract xml:lang="ru"><p/></trans-abstract><kwd-group xml:lang="ru"><kwd>иммуносупрессия</kwd><kwd>дендритные клетки</kwd><kwd>опухолевое микроокружение</kwd><kwd>регуляторные дендритные клетки</kwd><kwd>цитокины</kwd><kwd>immunosuppression</kwd><kwd>dendritic cells</kwd><kwd>tumor microenvironment</kwd><kwd>regulatory dendritic cells</kwd><kwd>cytokines</kwd></kwd-group></article-meta></front><body></body><back><ref-list><ref id="B1"><label>1.</label><mixed-citation>Zhong H., Shurin M.R., Han B. Optimizing dendritic cell-based immunotherapy for cancer. Expert Rev Vaccines 2007; 6(3): 333-45. DOI: 10.1586/14760584.6.3.333. PMID: 17542749.</mixed-citation></ref><ref id="B2"><label>2.</label><mixed-citation>Ma Y., Shurin G.V., Gutkin D.W. et al. Tumor associated regulatory dendritic cells. Seminars in cancer biology 2012; 22(4): 298-306. 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