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<article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:ali="http://www.niso.org/schemas/ali/1.0/" article-type="other" dtd-version="1.2" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">Russian Journal of Biotherapy</journal-id><journal-title-group><journal-title xml:lang="en">Russian Journal of Biotherapy</journal-title><trans-title-group xml:lang="ru"><trans-title>Российский биотерапевтический журнал</trans-title></trans-title-group></journal-title-group><issn publication-format="print">1726-9784</issn><issn publication-format="electronic">1726-9792</issn><publisher><publisher-name xml:lang="en">Publishing House ABV Press</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="publisher-id">840</article-id><article-id pub-id-type="doi">10.17650/1726-9784-2016-15-4-65-71</article-id><article-categories><subj-group subj-group-type="toc-heading" xml:lang="en"><subject>ORIGINAL REPORTS</subject></subj-group><subj-group subj-group-type="toc-heading" xml:lang="ru"><subject>ОРИГИНАЛЬНЫЕ СТАТЬИ</subject></subj-group><subj-group subj-group-type="article-type"><subject></subject></subj-group></article-categories><title-group><article-title xml:lang="en">MODELING OF A SUBCUTANEOUS XENOGRAFT OF HUMAN SKIN MELANOMA MEL CHER WITH V600E BRAF MUTATION IN IMMUNODEFICIENT MICE FOR PRECLINICAL STUDY THE TARGETING ANTICANCER DRUGS</article-title><trans-title-group xml:lang="ru"><trans-title>Mоделирование подкожного ксенографта меланомы кожи человека mel Cher с мутацией V600E BRAF на иммунодефицитных мышах для доклинического изучения таргетных противоопухолевых средств</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Andronova</surname><given-names>N. V.</given-names></name><name xml:lang="ru"><surname>Андронова</surname><given-names>Н. В.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Morozova</surname><given-names>L. F.</given-names></name><name xml:lang="ru"><surname>Морозова</surname><given-names>Л. Ф.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Mikhailova</surname><given-names>I. N.</given-names></name><name xml:lang="ru"><surname>Михайлова</surname><given-names>И. Н.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Lushnikova</surname><given-names>A. A.</given-names></name><name xml:lang="ru"><surname>Лушникова</surname><given-names>А. А.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Ponkratova</surname><given-names>D. A.</given-names></name><name xml:lang="ru"><surname>Понкратова</surname><given-names>Д. А.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Raychlin</surname><given-names>N. T.</given-names></name><name xml:lang="ru"><surname>Райхлин</surname><given-names>Н. Т.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Bukaeva</surname><given-names>I. A.</given-names></name><name xml:lang="ru"><surname>Букаева</surname><given-names>И. А.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Borisova</surname><given-names>U. A.</given-names></name><name xml:lang="ru"><surname>Борисова</surname><given-names>Ю. А.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Sitdikova</surname><given-names>S. M.</given-names></name><name xml:lang="ru"><surname>Ситдикова</surname><given-names>Сурия Мансуровна</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><email>suriyasitdikova@yandex.ru</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Treshalina</surname><given-names>H. M.</given-names></name><name xml:lang="ru"><surname>Трещалина</surname><given-names>Е. М.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><xref ref-type="aff" rid="aff1"/></contrib></contrib-group><aff id="aff1"><institution>ФГБУ «Российский онкологический научный центр им. Н.Н. Блохина» Минздрава России</institution></aff><content-language>ru</content-language><pub-date date-type="pub" publication-format="electronic" iso-8601-date="2016-12-30"><day>30</day><month>12</month><year>2016</year></pub-date><pub-date date-type="collection"><year>2016</year></pub-date><volume>15</volume><issue>4</issue><fpage>65</fpage><lpage>71</lpage><history><date date-type="received" iso-8601-date="2018-04-10"><day>10</day><month>04</month><year>2018</year></date></history><pub-history><event event-type="received"><event-desc>Received:<date date-type="received" iso-8601-date="2018-04-10"><day>10</day><month>04</month><year>2018</year></date></event-desc></event><event event-type="pub"><event-desc>Published:<pub-date date-type="pub" publication-format="electronic" iso-8601-date="2016-12-30"><day>30</day><month>12</month><year>2016</year></pub-date></event-desc></event></pub-history><permissions/><self-uri xlink:href="https://bioterapevt.abvpress.ru/jour/article/view/840">https://bioterapevt.abvpress.ru/jour/article/view/840</self-uri><abstract xml:lang="en"><p/></abstract><trans-abstract xml:lang="ru"><p/></trans-abstract><kwd-group xml:lang="ru"><kwd>пигментированная меланома кожи человека</kwd><kwd>мутация V600E BRAF</kwd><kwd>подкожный ксенографт</kwd><kwd>иммунодефицитная мышь</kwd><kwd>human pigmented skin melanoma</kwd><kwd>V600E BRAF mutation</kwd><kwd>subcutaneous xenograft</kwd><kwd>immunodeficient mice</kwd></kwd-group></article-meta></front><body></body><back><ref-list><ref id="B1"><label>1.</label><mixed-citation>Вишневская Я.В., Машенкина Я.А., Сендерович А.И. и др. 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