Russian Journal of BiotherapyRussian Journal of BiotherapyРоссийский биотерапевтический журнал1726-97841726-9792Publishing House ABV Press83510.17650/1726-9784-2016-15-4-40-43BRIEF REPORTКРАТКИЕ СООБЩЕНИЯREDOX DENDRIMERSОкислительно-восстановительные дендримерыStukalovYu. V.СтукаловЮ. В.
Russian Federation
GrigorievaE. Yu.ГригорьеваЕлена Юрьевна
Russian Federation
grig-elen11@mail.ruKalyginaN. S.КалыгинаН. С.
Russian Federation
KoldaevaE. Yu.КолдаеваЕ. Ю.
Russian Federation
MaskoA. S.МаськоА. С.
Russian Federation
ФГБУ «Российский онкологический научный центр им. Н.Н. Блохина» Минздрава России30122016154404310042018https://bioterapevt.abvpress.ru/jour/article/view/835

Aim of this work was the synthesis of REDOX-dendrimer core, which is tetraglycidyl ether of pentaerythritol, and a dendron, which is a derivative of anthraquinone. Materials and methods. Analytical and preparative chromatography was carried out on a liquid chromatograph SP 8000 (Spectra-Physics (USA)). Chromatograms were recorded using a UV-detector (Spectra-Physics (USA)) and refractive index detector (Jobin-Ivon (France)). The structure was confirmed by PMR (Bruker WH-360 (Germany)) with an operating frequency of 360 MHz. Monitoring of reactions conducted using HPLC. Results. Derivatives of 2-methylanthraquinone were synthesized and isolated by use of preparative HPLC. Their structure was determined by PMR-spectroscopy. They were used as a dendron in the synthesis of dendrimer. Its toxicity was studied in male mice ВDF1. Redox dendrimers containing methylanthraquinone derivatives in its structure were synthetized. Low toxicity of obtained REDOX-dendrimer was shown. Conclusion. The similarity of REDOX-dendrimer structure with doxorubicin and its low toxicity provides background for further study of its antitumor activity.

REDOX-дендримерпроизводные 2-метилантрахинонатетраглицидиловый эфир пентаэритритавысокоэффективная жидкостная хроматографиятоксикологияREDOX-dendrimerderivatives 2-methylanthraquinonetetraglycidyl ether of pentaerythritolHPLCtoxicologyTekade R.K., Kumar P.V., Jain N.K. et al. Dendrimers in Oncology: An Expanding Horizon. Chem Rev 2009;109(1):49-87. DOI: 10.1021/cr068212n.Стукалов Ю.В., Масько А.С., Калыгина Н.С. и др. Дендримеры как основа наноконструкций для таргетной радиотерапии в онкологии. Российский биотерапевтический журнал 2010;9(3):24.Колдаева Е.Ю., Григорьева Е.Ю., Стукалов Ю.В. и др. Сравнительная токсикология наноконструкций на основе дендримеров для таргетной радиотерапии в онкологии. Российский биотерапевтический журнал 2010;9(3):14.Hua D.H., Lou K., Havens J. et al. Synthesis and in vitro antitumor activity of substituted anthracene-1,4-diones. Tetrahedron 2004;60(45):10155-10163. DOI: 10.1016/j.tet.2004.09.026.Campos-Martin J.M., Blanco-Brieva G., Fierro J.L. G. Hydrogen Peroxide Synthesis: An Outlook beyond the Anthraquinone Process. Angewandte Chemie International Edition 2006;45(42):6962-84. DOI: 10.1002/anie.200503779.Sarvari M.H., Sharghi H. Simple and Improved Procedure for the Regioselective Acylation of Aromatic Ethers with Carboxylic Acids on the Surface of Graphite in the Presence of Methanesulfonic Acid. Synthesis 2004;13:2165-8. DOI: 10.1055/s-2004-831162.Kida T., Yokota M., Masuyama A. et al. A Facile Synthesis of Polyglycidyl Ethers from Polyols and Epichlorohydrin. Synthesis 1993;5:487-489. DOI: 10.1055/s-1993-25890.Коддаева Е.Ю., Стукалов Ю.В., Григорьева Е.Ю., Масько А.С. Острая токсичность REDOX-дендримеров. Российский биотерапевтический журнал 2012;11(2):26.Стукалов Ю.В., Колдаева Е.Ю., Кадырова Е.Л., Григорьева Е.Ю. Токсикология окислительно-восстановительных наноконструкций противоопухолевых препаратов. Российский биотерапевтический журнал 2011;10(4):111-2.