Russian Journal of BiotherapyRussian Journal of BiotherapyРоссийский биотерапевтический журнал1726-97841726-9792Publishing House ABV Press2410.17650/1726-9784-2015-14-2-91-98ORIGINAL REPORTSОРИГИНАЛЬНЫЕ СТАТЬИSMALL GTPASE ARF6 ACTIVATES mTORCl-DEPENDENT SIGNALING PATHWAY AND STIMULATES GLIOBLASTOMA CELL GROWTHМАЛАЯ ГТФаза ARF6 АКТИВИРУЕТ MTORC 1-ЗАВИСИМЫЙ СИГНАЛЬНЫЙ ПУТЬ И СТИМУЛИРУЕТ РОСТ КЛЕТОК ГЛИОБЛАСТОМЫZhuravskayaA. Yu.ЖуравскаяАнна Юрьевна
Russian Federation
iurkasun@gmail.comKomelkovA. V.КомельковА. В.
Russian Federation
TchevkinaE. M.ЧевкинаЕ. М.
Russian Federation
ФГБУ «РОНЦ им. Н.Н. Блохина»30062015142919810042018https://bioterapevt.abvpress.ru/jour/article/view/24

In this study we first identified role of small GTPase Arf6 in stimulation of proliferation and autonomous growth of human glioblastoma cells. We revealed that Arf6 activates the mTOR complex 1 (mTORCl) and this process is appeared to be an alternative mechanism of mTORC1-signaling activation, independent of PI3K/Akt-signaling pathway. We also showed that Arf6 is a negative regulator of protein kinase ERK1/2 in glioblastoma cells.

В работе впервые идентифицировано участие малой ГТФазы Arf6 в стимуляции пролиферации и автономного роста клеток глиобластомы. Показано, что белок Arf6 активирует комплекс mTORO, и этот процесс представляет собой альтернативный, независимый от PISK/Akt-сигнального каскада, механизм активации mTORCl-зависимого пути. Кроме того, обнаружено, что Arf6 является негативным регулятором протеинкиназы ERK1/2 в клетках глиобластомы.

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