Russian Journal of BiotherapyRussian Journal of BiotherapyРоссийский биотерапевтический журнал1726-97841726-9792Publishing House ABV Press120010.17650/1726-9784-2019-19-2-22-30REVIEWSОБЗОРЫ ЛИТЕРАТУРЫRECONSTITUTION OF B-CELLS IMMUNITY AFTER ALLOGENEIC HEMATOPOIETIC STEM CELL TRANSPLANTATIONВОССТАНОВЛЕНИЕ В-КЛЕТОЧНОГО ИММУНИТЕТА ПОСЛЕ АЛЛОГЕННОЙ ТРАНСПЛАНТАЦИИ ГЕМОПОЭТИЧЕСКИХ СТВОЛОВЫХ КЛЕТОКhttps://orcid.org/0000-0003-4412-5019ChulkovaS. V.ЧулковаС. В.
Russian Federation

24 Kashirskoe Shosse, Moscow 115478

1 Ostrovitianov St., Moscow 117997

Светлана Васильевна Чулкова

115478 Москва, Каширское шоссе, 24

117997 Москва, ул. Островитянова, 1а

chulkova@mail.ruSubbotinaN. N.СубботинаН. Н.
Russian Federation

5, 2 nd Botkinskiy Proezd, Moscow 125284

125284 Москва, 2-й Боткинский проезд, 5

PetrovaG. D.ПетроваГ. Д.
Russian Federation

24 Kashirskoe Shosse, Moscow 115478

115478 Москва, Каширское шоссе, 24

https://orcid.org/0000-0003-3797-5808SidorovaN. V.СидороваН. В.
Russian Federation

24 Kashirskoe Shosse, Moscow 115478

115478 Москва, Каширское шоссе, 24

https://orcid.org/0000-0001-8493-9012KolbatskayaO. P.КолбацкаяО. П.
Russian Federation

24 Kashirskoe Shosse, Moscow 115478

115478 Москва, Каширское шоссе, 24

https://orcid.org/0000-0003-3966-128XTupitsynN. N.ТупицынН. Н.
Russian Federation

24 Kashirskoe Shosse, Moscow 115478

115478 Москва, Каширское шоссе, 24

https://orcid.org/0000-0002-2337-3307NurtazinаA. Yu.НуртазинаА. Ю.
Russian Federation

8 Build 2, Trubetskaya St., Moscow 119991

119991 Москва, ул. Трубецкая, 8, стр. 2

N.N. Blokhin National Medical Research Center of Oncology of the Ministry of Health of the Russian FederationФГБУ «Национальный медицинский исследовательский центр онкологии им. Н.Н. Блохина» Минздрава РоссииN.I. Pirogov Russian National Research Medical UniversityФГAOУ ВО «Российский национальный исследовательский медицинский университет им. Н.И. Пирогова» Минздрава РоссииClinical Hospital “MEDSI”Клиническая больница «МЕДСИ»Sechenov First Moscow State Medical University, Ministry of Health of RussiaФГАОУ ВО Первый Московский государственный медицинский университет им. И.М. Сеченова Минздрава России (Сеченовский Университет)1806202019222301706202017062020https://bioterapevt.abvpress.ru/jour/article/view/1200

The restoration of B-cell immunity is a key component of the success of allogeneic hematopoietic stem cell transplantation. In most cases, the restoration of B-lymphopoiesis is a slow and often incomplete process, which is accompanied by a decrease in the tolerance of the recipient to bacterial, viral, fungal pathogens. This process is influenced by a number of factors that determine its effectiveness and pace. It is important to restore not only the size of the B-cell population, but also their functional usefulness. The article provides an analysis of modern literature data on the significance of the restoration of B-cell immunity after allogeneic hematopoietic stem cell transplantation, a review of the main factors affecting the process of B-lymphopoiesis, and their prognostic component.

Восстановление В-клеточного звена иммунитета – это ключевая составляющая успешности аллогенной трансплантации гемопоэтических стволовых клеток. В большинстве случаев восстановление В-лимфопоэза является медленным и часто незавершенным процессом, который сопровождается снижением толерантности реципиента к бактериальным, вирусным, грибковым патогенам. На этот процесс оказывает влияние ряд факторов, определяющих его эффективность и темп. Важно восстановление не только численности В-клеточной популяции, но и их функциональной полноценности. В статье проводится анализ современных данных литературы о значимости восстановления В-клеточного иммунитета после аллогенной трансплантации гемопоэтических стволовых клеток, обзор основных факторов, влияющих на процесс В-лимфопоэза, и их прогностической составляющей.

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