Russian Journal of BiotherapyRussian Journal of BiotherapyРоссийский биотерапевтический журнал1726-97841726-9792Publishing House ABV Press1210.17650/1726-9784-2015-14-2-7-16REVIEWSОБЗОРЫ ЛИТЕРАТУРЫBASIC DETERMINANTS OF MELANOMA STEM CELLОСНОВНЫЕ ДЕТЕРМИНАНТЫ СТВОЛОВОЙ КЛЕТКИ МЕЛАНОМЫVartanianA. A.ВартанянАмалия Арташевна
Russian Federation
zhivotov57@mail.ruOborotovaM. V.ОборотоваМ. В.
Russian Federation
ФГБНУ «РОНЦ им. Н.Н. Блохина»3006201514271610042018https://bioterapevt.abvpress.ru/jour/article/view/12

Melanoma is considered to be the deadliest form of skin cancer. For years it has been accepted that all melanoma cells in tumor are capable of tumor formation and each of them has the ability to initiate the metastasis. At present a stem cell theory of cancer has been developed, which purports that a subpopulation of self-renewing tumor cells is responsible for tumorogenesis, neoangiogenesis and stroma building. In this review we will discuss the basic determinants of melanoma stem cell and melanoma stem cell targeting implications.

Меланома - чрезвычайно злокачественная опухоль. До недавнего времени предполагалось, что все клетки меланомы обладают одинаковой способностью инициировать опухоль и формировать метастазы. Сегодня достоверно показано, что такими свойствами обладает немногочисленная субпопуляция особых самообновляющихся клеток, называемых стволовыми. Эти клетки ответственны за все проявления процесса формирования опухоли, включая неоангиогенез и образование стромы. В обзоре будут обсуждены основные антигенные детерминанты стволовой клетки меланомы, а также подходы к терапевтическому воздействию на СКМ.

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