Russian Journal of BiotherapyRussian Journal of BiotherapyРоссийский биотерапевтический журнал1726-97841726-9792Publishing House ABV Press119810.17650/1726-9784-2019-19-2-6-12REVIEWSОБЗОРЫ ЛИТЕРАТУРЫCURRENT POINT OF VIEW ON PROGNOSTIC AND PREDICTIVE ROLES AND PRACTICAL APPLICATION OF HER2 RECEPTOR’S DETECTION. LITERATURE REVIEWСОВРЕМЕННЫЕ ПРЕДСТАВЛЕНИЯ О ПРОГНОСТИЧЕСКОЙ/ПРЕДИКТИВНОЙ РОЛИ И ОЦЕНКЕ РЕЦЕПТОРА HER2 ПРИ РАКЕ ЖЕЛУДКА. ОБЗОР ЛИТЕРАТУРЫhttps://orcid.org/0000-0003-3386-0077RotinD. L.РотинД. Л.
Russian Federation

5 2 nd Botkinskiy proezd, Moscow 125284

125284 Москва, 2-й Боткинский проезд, 5, к. 33

https://orcid.org/0000-0001-6373-1888PaklinaO. V.ПаклинаО. В.
Russian Federation

5 2 nd Botkinskiy proezd, Moscow 125284

125284 Москва, 2-й Боткинский проезд, 5, к. 33

Tin’kovaI. O.ТиньковаИ. О.
Russian Federation

5 2 nd Botkinskiy proezd, Moscow 125284

Ирина Олеговна Тинькова

125284 Москва, 2-й Боткинский проезд, 5, к. 33

tinkovairen74@yandex.ruGrekovD. N.ГрековД. Н.
Russian Federation

5 2 nd Botkinskiy proezd, Moscow 125284

125284 Москва, 2-й Боткинский проезд, 5, к. 33

https://orcid.org/0000-0002-5262-4953SetdikovaG. R.СетдиковаГ. Р.
Russian Federation

5 2 nd Botkinskiy proezd, Moscow 125284

125284 Москва, 2-й Боткинский проезд, 5, к. 33

Botkin City clinical hospitalГБУЗ «Городская клиническая больница им. С.П. Боткина Департамента здравоохранения г. Москвы»180620201926121706202017062020https://bioterapevt.abvpress.ru/jour/article/view/1198

Human epidermal growth factor receptor HER2, a proto-oncogene involved in the proliferation and differentiation signaling pathway. The overexpression and amplification of the HER2 gene and their significance have been studied in breast cancer. Data on HER2 over expression in gastric cancer vary widely, and the value is presented by inconsistent disparate data. The interpretation of HER2 in gastric cancer differs from the evaluation in breast cancer. The purpose of this review is to summarize current data on the evaluation of HER2 in gastric cancer for the selection of targeted therapy. The search in modern databases of medical literature was carried out, more than 100 modern literary sources on the above-mentioned topic were studied and analyzed in detail and carefully. The most significant data on the evaluation of HER2 expression in gastric cancer and its prognostic and predictive value were selected and presented. Selected options evaluate the expression of HER2 receptor in operating and biopsy material of stomach cancer. Comparative data on the use of different antibody clones to solve the above problem are presented. The most frequent and important errors and possible interpretation disorders in the expression of HER2 in gastric cancer are analyzed. The use of transtuzumab for targeted therapy in gastric cancer makes it mandatory to test surgical and biopsy samples of gastric cancer to assess their expression of HER2. The development of various methods and the progress of molecular biology, however, the main role of the immunohistochemical method in solving this problem still left. Gastric cancer needs a single accessible standardized system for evaluating HER2 expression, and, most importantly, expert level interpretation of these results.

Рецептор 2 эпидермального фактора роста человека (HER2) – протоонкоген, участвующий в передаче сигналов пролифера ции и дифференцировки. Гиперэкспрессия и амплификация гена HER2 хорошо изучены при раке молочной железы. Данные о гиперэкспрессии HER2 при раке желудка (РЖ) широко варьируют, часто разрозненны. Интерпретация HER2 при РЖ и раке молочной железы отличается. Этот обзор суммирует сведения, касающиеся оценки HER2 при РЖ для подбора таргетной терапии. В базах данных медицинской литературы был проведен поиск, изучены и проанализированы более 100 современных источников по теме. Отобраны и изложены самые значимые – об оценке экспрессии HER2 при РЖ, его прогностическом/предиктивном значении. В результате выделены варианты оценки экспрессии рецептора HER2 в операционном и биопсийном материале РЖ. Приведены сравнительные данные о применении различных клонов антител для решения названной задачи. Разобраны наиболее частые и важные ошибки и возможные нарушения интерпретации в экспрессии HER2 при РЖ. Применение трастузумаба для таргетной терапии при РЖ делает обязательным тестирование операционного и биопсийного материала в отношении экспрессии HER2. Прогресс различных методов молекулярной биологии оставляет иммуногистохимии основную роль в решении данной задачи. Дальнейшее исследование РЖ нуждается в единой стандартизованной системеоценки экспрессии HER2, интерпретации результатов.

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