Russian Journal of BiotherapyRussian Journal of BiotherapyРоссийский биотерапевтический журнал1726-97841726-9792Publishing House ABV Press118810.17650/1726-9784-2019-19-1-22-52REVIEWSОБЗОРЫ ЛИТЕРАТУРЫSTEROID CONJUGATES AS POTENTIAL ANTI-CANCER AGENTSСТЕРОИДНЫЕ КОНЪЮГАТЫ КАК ПОТЕНЦИАЛЬНЫЕ ПРОТИВООПУХОЛЕВЫЕ АГЕНТЫhttps://orcid.org/0000-0002-2067-5887ZolottsevV. A.ЗолотцевВ. А.
Russian Federation
https://orcid.org/0000-0001-6669-5739LatyshevaA. S.ЛатышеваА. С.
Russian Federation
https://orcid.org/0000-0003-4006-9320PokrovskyV. S.ПокровскийВ. С.
Russian Federation

Вадим Сергеевич Покровский

vadimpokrovsky@yandex.ruKhanI. I.ХанИ. И.
Russian Federation
AlmanzaR. L. M.АлманзаР.Л. М.
Russian Federation
MisharinA. Y.МишаринА. Ю.
Russian Federation
Institute of Biomedical ChemistryФГБНУ «Научно-исследовательский институт биомедицинской химии им. В.Н. Ореховича»N.N. Blokhin National Medical Research Center of Oncology of the Ministry of Health of the Russian FederationФГБУ «Национальный медицинский исследовательский центр онкологии им. Н.Н. Блохина» Минздрава РоссииPeoples’ Friendship University of Russia (RUDN University)ФГАОУ ВО «Российский университет дружбы народов»2203202019122522203202022032020https://bioterapevt.abvpress.ru/jour/article/view/1188

The review is dedicated to results of investigations of steroid conjugates published predominantly over the past decade. It consists of three parts in which the data concerning biological activity of steroid conjugates with known drugs, steroid dimers, and steroid conjugates with some natural compounds, their fragments and related derivatives and analogs, are discussed. The structures of 231 steroid conjugates and their anti-cancer properties are presented.

Обзор посвящен результатам исследований новых стероидных конъюгатов, имеющих перспективу использования в качестве противоопухолевых лекарственных препаратов. Обзор состоит из 3 частей, в которых представлены данные о биологической активности конъюгатов стероидов с известными лекарственными препаратами, стероидных димеров и конъюгатов стероидов с различными природными соединениями, их фрагментами и синтетическими аналогами. Приведены структуры 231 стероидного конъюгата и данные об их противоопухолевой активности.

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