Russian Journal of BiotherapyRussian Journal of BiotherapyРоссийский биотерапевтический журнал1726-97841726-9792Publishing House ABV Press118610.17650/1726-9784-2019-19-1-6-12REVIEWSОБЗОРЫ ЛИТЕРАТУРЫPAPILLOMAVIRAL CARCINOGENESIS. MAJOR ACHIEVEMENTS AND CERTAIN CHALLENGES PART I. GENERAL NOTIONS OF PAPILLOMAVIRUSES. HUMAN PAPILLOMAVIRUSES-ASSOCIATED CANCERSПАПИЛЛОМАВИРУСНЫЙ КАНЦЕРОГЕНЕЗ. ОСНОВНЫЕ ДОСТИЖЕНИЯ И НЕКОТОРЫЕ ПРОБЛЕМЫ ЧАСТЬ 1. ОБЩИЕ ПРЕДСТАВЛЕНИЯ О ПАПИЛЛОМАВИРУСАХ. ФОРМЫ РАКА, АССОЦИИРОВАННЫЕ С ВИРУСАМИ ПАПИЛЛОМЫ ЧЕЛОВЕКАhttps://orcid.org/0000-0002-6817-2103VolgarevaG. M.ВолгареваГ. М.
Russian Federation

Галина Михайловна Волгарева

galina.volgareva@ronc.ruN.N. Blokhin National Medical Research Center of Oncology of the Ministry of Health of the Russian FederationФГБУ «Национальный медицинский исследовательский центр онкологии им. Н.Н. Блохина» Минздрава России220320201916122203202022032020https://bioterapevt.abvpress.ru/jour/article/view/1186

Development of three vaccines intended to prevent cervical cancer (CC) caused by oncogenic human papillomaviruses (HPV) appears to be principal result of research into papillomaviral carcinogenesis. Two of these vaccines efficient in prophylaxis of about 70 % of new CC cases have been recommended for application in Russia. Up till now preventive HPV-vaccinations are not included into the Russian National Vaccination Shedule. In addition to CC HPV are known as etiological agents of some other anogenital as well as certain head and neck tumors. The overall cancer statistics data are found to vary owing to socioeconomic inequalities extremely dramatically for the most preventable cancers. The review is dedicated to major achievements and certain challenges in the field of oncogenic HPV studies.

Важнейшим результатом исследований в области папилломавирусного канцерогенеза явилось создание 3 вакцин, предназначенных для профилактики рака шейки матки (РШМ), вызываемого онкогенными вирусами папилломы человека (ВПЧ). Две из этих вакцин, которые могут предупредить до 70 % новых случаев РШМ, рекомендованы к применению в России. До настоящего времени профилактические ВПЧ-вакцинации в России не включены в национальный календарь прививок. Помимо РШМ, ВПЧ являются этиологическими агентами при ряде других опухолей аногенитальной сферы, а также новообразований головы и шеи. Установлено, что наибольший разрыв в показателях онкологической статистики между разными регионами мира, обусловленный социоэкономическими факторами, выявляется по отношению именно к тем злокачественным новообразованиям, для которых существуют эффективные способы предупреждения. Обзор посвящен основным достижениям в области изучения онкогенных ВПЧ, а также ряду нерешенных проблем.

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