Russian Journal of BiotherapyRussian Journal of BiotherapyРоссийский биотерапевтический журнал1726-97841726-9792Publishing House ABV Press117710.17650/1726-9784-2019-18-4-34-42REVIEWSОБЗОРЫ ЛИТЕРАТУРЫUSE OF BACTERIA IN CANCER THERAPY (REVIEW)ИСПОЛЬЗОВАНИЕ БАКТЕРИЙ ДЛЯ ЛЕЧЕНИЯ ОНКОЛОГИЧЕСКИХ ЗАБОЛЕВАНИЙ (ОБЗОР )DarmovI. V.ДармовИ. В.
Russian Federation

119 Oktyabr’skiy Prospekt, Kirov 610000, Russia

Россия, 610000 Киров, Октябрьский проспект, 119

KibirevYa. A.КибиревЯ. А.
Russian Federation

119 Oktyabr’skiy Prospekt, Kirov 610000, Russia

Россия, 610000 Киров, Октябрьский проспект, 119

23527@mail.ruMarakulinI. V.МаракулинИ. В.
Russian Federation

119 Oktyabr’skiy Prospekt, Kirov 610000, Russia

Россия, 610000 Киров, Октябрьский проспект, 119

YanovS. N.ЯновС. Н.
Russian Federation

119 Oktyabr’skiy Prospekt, Kirov 610000, Russia

Россия, 610000 Киров, Октябрьский проспект, 119

Branch of the Federal State Establishment “48 Central Research and Development Institute” Russian Federation Ministry of Defense (Kirov)Филиал ФГБУ «48 Центральный научно-исследовательский институт» Минобороны России0212201918434423011201930112019https://bioterapevt.abvpress.ru/jour/article/view/1177

Bacterial drugs for the treatment of malignant tumors have been discovered more than a hundred years ago, but their use in clinical practice has been very limited. In the past decade, there has been a revival of interest in the development of bacterial-based cancer biotherapies, which is associated with advances in genetic engineering and in depth knowledge of the mechanisms of the infectious process and immunity. The purpose of this review is to examine the current state and prospects for the development and use of drugs based on live bacterium, intended for the treatment of malignant tumors. The review presents evaluation data on experimental models of the antitumor potential of various species and strains of bacteria; the most significant results of clinical trials of bacterial antitumor agents; current trends in the design of bacterial strains for targeted drug delivery to the tumor. It is concluded that development of bacterial drugs for cancer therapy is a perspective branch of experimental oncology.

Бактериальные средства лечения злокачественных новообразований известны уже более ста лет, однако в клинике они нашли весьма ограниченное применение. В последнее десятилетие отмечается возрождение интереса к разработке средств биотерапии рака на основе бактерий, что связано с прогрессом в области генной инженерии и глубоким познанием механизмов инфекционного процесса и иммунитета. Целью настоящего обзора является рассмотрение современного состояния и перспектив разработки и применения препаратов на основе живых бактерий, предназначенных для лечения злокачественных опухолей. В обзоре представлены данные оценки на экспериментальных моделях противоопухолевого потенциала различных видов и штаммов бактерий; наиболее значимые результаты клинических испытаний бактериальных противоопухолевых средств; современные направления конструирования бактериальных штаммов как средств адресной доставки лекарственных субстанций в опухоли. Сделано заключение о том, что разработка бактериальных средств терапии рака является перспективным направлением экспериментальной онкологии.

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