Russian Journal of BiotherapyRussian Journal of BiotherapyРоссийский биотерапевтический журнал1726-97841726-9792Publishing House ABV Press117610.17650/1726-9784-2019-18-4-25-33REVIEWSОБЗОРЫ ЛИТЕРАТУРЫDOPAMINERGIC SYSTEM: STRESS, DEPRESSION AND CANCER (PART 2)ДОФАМИНЕРГИЧЕСКАЯ СИСТЕМА: СТРЕСС, ДЕПРЕССИЯ, РАК (ЧАСТЬ 2)https://orcid.org/0000-0002-6365-2888BocharovaO. A.БочароваО. А.
Russian Federation

24 Kashirskoye Shosse, Moscow 115478, Russia

Россия, 115478 Москва, Каширское шоссе, 24

imufarm@rambler.ruhttps://orcid.org/0000-0003-2342-9881BocharovE. V.БочаровЕ. В.
Russian Federation

24 Kashirskoye Shosse, Moscow 115478, Russia

Россия, 115478 Москва, Каширское шоссе, 24

https://orcid.org/0000-0002-5071-3581KucheryanuV. G.КучерянуВ. Г.
Russian Federation

8 Baltiyskaya St., Moscow 125315, Russia

Россия, 125315 Москва, ул. Балтийская, 8

https://orcid.org/0000-0003-4893-1472KarpovaR. V.КарповаР. В.
Russian Federation

24 Kashirskoye Shosse, Moscow 115478, Russia

Россия, 115478 Москва, Каширское шоссе, 24

VershinskayaA. A.ВершинскаяА. А.
Russian Federation

24 Kashirskoye Shosse, Moscow 115478, Russia

Россия, 115478 Москва, Каширское шоссе, 24

N.N. Blokhin National Medical Research Center of Oncology of the Ministry of Health of the Russian FederationФГБУ «Национальный медицинский исследовательский центр онкологии им. Н. Н. Блохина» Минздрава РоссииInstitute of general pathology and pathophysiologyФГБНУ «Научно-исследовательский институт общей патологии и патофизиологии»0212201918425333011201930112019https://bioterapevt.abvpress.ru/jour/article/view/1176

In today’s world, we are constantly exposed to stress. At the same time, if acute stress can have a positive effect on the body, constant stress usually harms health, leading to serious diseases, including cancer, which is considered to be age-related disease. It is also known that stress can significantly deteriorate the efficacy of chemotherapies and anti-tumour immune response, promote tumor growth and metastasis spreading. Meanwhile dopamin known to be antiaging and antistress agent is able to inhibit tumourgenesis. Therefore the role of Central neuronal processes involving the dopaminergic system in the mechanisms of malignant growth control is discussed in the present review.

Во многих ситуациях в современном мире мы подвержены стрессу. Вместе с тем, если острый стресс может иметь положительное воздействие на организм, постоянное стрессирование, как правило, наносит вред здоровью, приводя к серьезным заболеваниям, в том числе к раку, который считают болезнью старения. Выявлено, что стресс может ускорять опухолевый рост, ослаблять противоопухолевый иммунитет и эффективность химиотерапии. Из данных литературы известно, что дофамин, недостаток которого играет существенную роль при старении и стрессе, ограничивает развитие опухолей. Роль центральных нейрональных процессов с участием дофаминергической системы в механизмах контроля злокачественного роста обсуждается в представленном обзоре.

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