Russian Journal of BiotherapyRussian Journal of BiotherapyРоссийский биотерапевтический журнал1726-97841726-9792Publishing House ABV Press117510.17650/1726-9784-2019-18-4-17-24REVIEWSОБЗОРЫ ЛИТЕРАТУРЫMICROSATELLITE INSTABILITY AND GASTRIC CARCINOMA. REVIEW OF THELITERATUREМИКРОСАТЕЛЛИТНАЯ НЕСТАБИЛЬНОСТЬ И КАРЦИНОМА ЖЕЛУДКА. ОБЗОР ЛИТЕРАТУРЫhttps://orcid.org/0000-0003-3386-0077RotinD. L.РотинД. Л.
Russian Federation

5 Second Botkinskyi Proyezd, Moscow 125284, Russia

Россия, 125284 Москва, 2‑й Боткинский проезд, 5

https://orcid.org/0000-0001-6373-1888PaklinaO. V.ПаклинаО. П.
Russian Federation

5 Second Botkinskyi Proyezd, Moscow 125284, Russia

Россия, 125284 Москва, 2‑й Боткинский проезд, 5

Tin’kovaI. O.ТиньковаИ. О.
Russian Federation

5 Second Botkinskyi Proyezd, Moscow 125284, Russia

Россия, 125284 Москва, 2‑й Боткинский проезд, 5

tinkovairen74@yandex.ruGrekovD. N.ГрековД. Н.
Russian Federation

5 Second Botkinskyi Proyezd, Moscow 125284, Russia

Россия, 125284 Москва, 2‑й Боткинский проезд, 5

S. P. Botkin City Clinical HospitalГБУЗ «Городская клиническая больница им. С. П. Боткина Департамента здравоохранения г. Москвы»0212201918417243011201930112019https://bioterapevt.abvpress.ru/jour/article/view/1175

Carcinoma of the stomach is wide spread malignancy with the poor prognosis. Recent investigations of the genome features let to consider this tumor as heterogeneous lesion, presenting different biological subtypes. Each of those subtypes has its own definitive characteristics including difference in prognosis. Microsatellite instability (MSI) – epigenetic molecular abnormality known in many tumors. The role of MSI in the carcinoma of stomach, prognostic as well predictive, is still not clear. High incidence (10 up to 22 %) of MSI in carcinoma of stomach requires performing more extensive studying of this malignancy. The present review is dedicated to recent data of the literature, concerning clinical, morphological, prognostic and predictive features of MSI in the carcinoma of stomach.

Рак желудка (РЖ) – широко распространенная злокачественная опухоль с плохим прогнозом. Последние исследования характеристик генома позволяют рассматривать РЖ как гетерогенное заболевание, представленное различными биологическими подтипами, каждый из которых имеет свои специфические свойства и признаки с различным прогнозом. Микросателлитная нестабильность (МСН) – эпигенетическое молекулярное нарушение, известное во многих опухолях. Роль МСН в РЖ, как прогностическая, так и предиктивная, не вполне ясна. Частая встречаемость (от 10 до 22 %) РЖ с МСН требует более интенсивного изучения ее роли в данной опухоли. Данный обзор посвящен современным данным литературы, касающимся клинических, морфологических, прогностических и предиктивных свойств МСН в РЖ.

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Microsatellite instability in gastric cancer: molecular bases, clinical perspectives, and new treatment approaches. Cell Mol Life Sci 2018;75(22):4151–62.