Russian Journal of BiotherapyRussian Journal of BiotherapyРоссийский биотерапевтический журнал1726-97841726-9792Publishing House ABV Press116610.17650/1726-9784-2019-18-3-15-22REVIEWSОБЗОРЫ ЛИТЕРАТУРЫThe different roles of toll-like receptors in oncotherapyРазличные роли толл-подобных рецепторов в онкотерапииhttps://orcid.org/0000-0002-3878-3958TreshalinaE. M.ТрещалинаЕ. М.
Russian Federation

24 Kashyrskoe Shosse, Moscow 115478.

15478 Москва, Каширское шоссе, 24.

treshalina@yandex.ruhttps://orcid.org/0000-0002-7659-6045MikhaylovaI. N.МихайловаИ. Н.
Russian Federation

24 Kashyrskoe Shosse, Moscow 115478.

15478 Москва, Каширское шоссе, 24.

https://orcid.org/0000-0002-0132-167XKiselevskiyM. V.КиселевскийМ. В.
Russian Federation

24 Kashyrskoe Shosse, Moscow 115478.

15478 Москва, Каширское шоссе, 24.

N.N. Blokhin National Medical Research Center of Oncology of the Ministry of Health of RussiaНациональный медицинский исследовательский центр онкологии им. Н.Н. Блохина Минздрава России1610201918315221410201914102019https://bioterapevt.abvpress.ru/jour/article/view/1166

The review considers and analyzes the literature data on the functions of the toll-like receptor family (TLR) in the development of malignant process. The structure of TLR, mechanisms of intracellular signal transduction, specific ligands antagonists and agonists of TLR are briefly reflected. Effects of various TLR from the point of view of influence on tumor growth and reactions of cellular immunity are given. The ambiguous results of experimental and clinical application of agonists and antagonists of TLR are compared. It is concluded that it is necessary to obtain additional information with the agonists of TLR at the stages of preclinical study.

В обзоре рассмотрены и проанализированы данные литературы о функциях семейства толл-подобных рецепторов (ТПР), значимых для опухолевого процесса, кратко отражены такие важные аспекты, как строение ТПР, механизмы внутриклеточной передачи сигнала, известные специфические лиганды и агонисты ТПР. Кроме того, описаны эффекты воздействия на различные ТПР с точки зрения влияния на рост самой опухоли и реакций клеточного иммунитета. Приведено сравнение неоднозначных результатов экспериментального изучения и клинического применения агонистов и антагонистов ТПР. Сделан вывод о необходимости получения информации об отсутствии стимуляции опухолевого роста in vivo агонистов ТПР на этапе доклинического изучения.

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