Russian Journal of BiotherapyRussian Journal of BiotherapyРоссийский биотерапевтический журнал1726-97841726-9792Publishing House ABV Press116510.17650/1726-9784-2019-18-3-6-14REVIEWSОБЗОРЫ ЛИТЕРАТУРЫDopaminergic system: stress, depression, cancer (part 1)Дофаминергическая система: стресс, депрессия, рак (часть 1)https://orcid.org/0000-0002-6365-2888BocharovaO. A.БочароваО. А.
Russian Federation

24 Kashirskoe Shosse, Moscow 115478.

115478 Москва, Каширское шоссе, 24.

imufarm@rambler.ruhttps://orcid.org/0000-0003-2342-9881BocharovE. V.БочаровЕ. В.
Russian Federation

24 Kashirskoe Shosse, Moscow 115478.

115478 Москва, Каширское шоссе, 24.

imufarm@rambler.ruhttps://orcid.org/0000-0002-5071-3581KucheryanuV. G.КучерянуВ. Г.
Russian Federation

8 Baltiyskaya St., Moscow 125315.

125315 Москва, ул. Балтийская, 8.

imufarm@rambler.ruhttps://orcid.org/0000-0003-4893-1472KarpovaR. V.КарповаР. В.
Russian Federation

24 Kashirskoe Shosse, Moscow 115478.

115478 Москва, Каширское шоссе, 24.

imufarm@rambler.ruN.N. Blokhin National Medical Research Center of Oncology of the Ministry of Health of RussiaНациональный медицинский исследовательский центр онкологии им. Н.Н. Блохина Минздрава РоссииInstitute of general pathology and pathophysiologyНаучно-исследовательский институт общей патологии и патофизиологии161020191836141410201914102019https://bioterapevt.abvpress.ru/jour/article/view/1165

The review discusses the functional features of the dopaminergic system. Dopamine synthesis is carried out both in the сentral nervous system and in the gastrointestinal tract. The first part of the review is devoted to the data of modern literature on the role of dopamine in the mechanisms of aging. At the same time, the processes underlying the depressive disorder in terms of the dopaminergic system participation integrating monoaminergic, epigenetic, inflammatory, neurotrophic and antiapoptic concepts are described.

В обзоре обсуждаются функциональные особенности дофаминергической системы. Синтез дофамина осуществляется как в центральной нервной системе, так и в желудочно-кишечном тракте. Первая часть обзора посвящена данным современной литературы о роли дофамина в механизмах старения. Вместе с тем описываются процессы, лежащие в основе депрессивного расстройства с точки зрения участия дофаминергической системы при интеграции моноаминергической, эпигенетической, воспалительной, нейротрофинной и антиапоптической концепций.

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