Russian Journal of BiotherapyRussian Journal of BiotherapyРоссийский биотерапевтический журнал1726-97841726-9792Publishing House ABV Press112010.17650/1726-9784-2018-17-4-6-19REVIEWSОБЗОРЫ ЛИТЕРАТУРЫOncolitical viruses in the therapy of malignant neoplastic diseasesОнколитические вирусы в терапии злокачественных новообразованийKlaanN. K.КлаанН. К.
Russian Federation

20, Usievicha St., A-190, Moscow 125190

125190 Москва, А-190, ул. Усиевича, 20

Наталья Константиновна Клаан 

biolog@viniti.ruАkin’shinaL. P.АкиньшинаЛ. П.
Russian Federation

20, Usievicha St., A-190, Moscow 125190

125190 Москва, А-190, ул. Усиевича, 20

ProninaT. A.ПронинаТ. А.
Russian Federation

20, Usievicha St., A-190, Moscow 125190

125190 Москва, А-190, ул. Усиевича, 20

All-Russian Institute Scientific and Technical InformationФГБУ «Всероссийский институт научной и технической информации»1112201817461909012019090120192018https://bioterapevt.abvpress.ru/jour/article/view/1120

The main types of oncolytic viruses and the mechanisms of their action on the tumor cells are described in this review. Examples of optimization of the viral genome are given with a view to enhancing the oncolytic properties of the virus. The achievements in the field of development of antitumour agents based on oncolytic viruses and methods of their application in oncology are described.

В обзоре охарактеризованы основные типы онколитических вирусов, рассмотрены механизмы их действия на опухолевую клетку. Приведены примеры оптимизации вирусного генома с целью усиления онколитических свойств вируса. Описаны достижения в области создания противоопухолевых средств на основе онколитических вирусов и способы их применения в онкологии.

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