Russian Journal of BiotherapyRussian Journal of BiotherapyРоссийский биотерапевтический журнал1726-97841726-9792Publishing House ABV Press111110.17650/1726-9784-2018-17-1-34-46REVIEWSОБЗОРЫ ЛИТЕРАТУРЫMechanisms of resistance to anti-Pd-1 therapy in metastatic cutaneous melanomaМеханизмы резистентности метастатической меланомы кожи к анти-Pd-1 терапииZhulikovYa. A.ЖуликовЯ.  А.
Russian Federation

Bldg. 2, 8 Trubetskaya St., Moscow 119991

119991 Москва, ул. Трубецкая, 8, стр. 2

SamoylenkoI. V.СамойленкоИ. В.
Russian Federation

24 Kashirskoe Shosse, Moscow 115478

115478 Москва, Каширское шоссе, 24

Игорь Вячеславович Самойленко

i.samoylenko@ronc.ruDemidovL. V.ДемидовЛ. В.
Russian Federation

24 Kashirskoe Shosse, Moscow 115478

115478 Москва, Каширское шоссе, 24

Sechenov UniversityФГАОУ ВО Первый МГМУ им. И.М. Сеченова Минздрава России (Сеченовский Университет)N.N. Blokhin National Medical Research Center of Oncology, Ministry of Health of RussiaФГБУ «НМИЦ онкологии им. Н.Н. Блохина» Минздрава России27022018171344627112018271120182018https://bioterapevt.abvpress.ru/jour/article/view/1111

The appearance of modulators immune synapse in clinical practice has become a revolution in metastatic skin melanoma treatment. However, blockade PD-1 allows to achieve objective response in only 30–40 % of patients. Recently, many mechanisms of primary resistance of melanoma to immunotherapy studied, they related both to the characteristics of the tumor and the tumor microenvironment. The response to anti-PD-1 therapy usually is durable, but acquired resistance emerges in 25 % of patients, who had an objective response to this treatment. This review will describe the main mechanisms of resistance to anti-PD-1 therapy in metastatic skin melanoma and possible ways of their overcoming.

Появление в клинической практике ингибиторов иммунных контрольных точек стало революцией в лечении метастатической меланомы кожи. Однако блокада PD-1 позволяет добиться объективного ответа лишь у 30–40 % пациентов. К настоящему времени известно множество механизмов первичной резистентности меланомы к иммунотерапии, связанных с особенностями как опухоли, так и опухолевого микроокружения. Как правило, ответ на анти-PD-1 терапию является длительным, но вторичная резистентность формируется у 25 % пациентов, имевших объективный ответ на данный вид лечения. В этом обзоре описаны основные механизмы резистентности метастатической меланомы кожи к анти-PD-1 терапии, а также возможные пути их преодоления.

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