Russian Journal of BiotherapyRussian Journal of BiotherapyРоссийский биотерапевтический журнал1726-97841726-9792Publishing House ABV Press109610.17650/1726-9784-2018-17-3-12-19REVIEWSОБЗОРЫ ЛИТЕРАТУРЫMetformin: new perspectives in chemoprevention and therapy of cancerМетформин: новые перспективыв химиопрофилактике и терапии ракаhttps://orcid.org/0000-0001-9648-8255ShestakovA. V.ШестаковА. В.
Russian Federation

2 Moskovskiy Trakt, Tomsk, 634050, Russia

634050 Томск, Московский тракт, 2

https://orcid.org/0000-0001-9011-8720SaprinaT. V.СапринаТ. В.
Russian Federation

2 Moskovskiy Trakt, Tomsk, 634050, Russia

Татьяна Владимировна Саприна

634050 Томск, Московский тракт, 2

tvsaprina@gmail.comhttps://orcid.org/0000-0002-8481-6562AnufrakI. A.АнуфракИ. А.
Russian Federation

2 Moskovskiy Trakt, Tomsk, 634050, Russia

634050 Томск, Московский тракт, 2

GonchikovaO. E.ГончиковаО. Э.
Russian Federation

2 Moskovskiy Trakt, Tomsk, 634050, Russia

634050 Томск, Московский тракт, 2

https://orcid.org/0000-0002-8194-2811ChernyshevaA. L.ЧернышеваА. Л.
Russian Federation

12/1 Savinykh St., Tomsk, 634028

Россия, 634028 Томск, ул. Савиных, 12/1

Siberian State Medical University, Ministry of Health of RussiaФГБОУ ВО «Сибирский государственный медицинский универститет» Минздрава РоссииTomsk National Research Medical Center, Russian Academy of Medical Sciences, Oncology Research InstituteФГБНУ «Томский национальный исследовательский медицинский центр Российской академии наук», НИИ онкологии2511201817312192511201825112018https://bioterapevt.abvpress.ru/jour/article/view/1096

According to modern data, metformin is a unique drug, which can act not only as sugar-reducing medicine, but also as an antiproliferative element. More and more new researches about metformin effects in oncologic patients appear during last decades. A lot of researchers suppose that metformin is a new promising medicine for chemopreventive and neoadjuvant cancer therapy. This literature review covers current researches of metformin in context of it»s possible antiproliferative effects.

Согласно современным данным метформин (МФ) является уникальным лекарственным средством, в котором сочетаются сахароснижающий и антипролиферативный эффекты. В последние десятилетия появляется все больше новых исследований на тему механизмов действия МФ и его эффективности у онкологических больных. Многие исследователи говорят о МФ как о потенциальном препарате для химиопрофилактики и адъювантной терапии разных типов рака. В данном обзоре рассмотрены актуальные исследования данного препарата в контексте его возможных антинеопластических эффектов. 

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