Russian Journal of BiotherapyRussian Journal of BiotherapyРоссийский биотерапевтический журнал1726-97841726-9792Publishing House ABV Press108410.17650/1726-9784-2018-17-2-22-30REVIEWSОБЗОРЫ ЛИТЕРАТУРЫEGFR Tyrosine kinase inhibitors in the treatment of metastases of non-small cell lung cancer in the brainИнгибиторы тирозинкиназы EGFR в лечении метастазов немелкоклеточного рака легкого EGFRm в головном мозгеNaskhletashviliD. R.НасхлеташвилиД. Р.
Russian Federation

24 Kashirskoe shosse, Moscow 115478

Давид Романович Насхлеташвили

115478 Москва, Каширское шоссе, 24

nas-david@yandex.ruGorbunovaV. A.ГорбуноваВ. А.
Russian Federation

24 Kashirskoe shosse, Moscow 115478

115478 Москва, Каширское шоссе, 24

BychkovM. B.БычковМ. Б.
Russian Federation

24 Kashirskoe shosse, Moscow 115478

115478 Москва, Каширское шоссе, 24

BekyashevA. Kh.БекяшевА. Х.
Russian Federation

24 Kashirskoe shosse, Moscow 115478

115478 Москва, Каширское шоссе, 24

KarakhanV. B.КараханВ. Б.
Russian Federation

24 Kashirskoe shosse, Moscow 115478

115478 Москва, Каширское шоссе, 24

AleshinV. A.АлешинВ. А.
Russian Federation

24 Kashirskoe shosse, Moscow 115478

115478 Москва, Каширское шоссе, 24

MoskvinaE. A.МосквинаЕ. А.
Russian Federation

24 Kashirskoe shosse, Moscow 115478

115478 Москва, Каширское шоссе, 24

N.N. Blokhin National Medical Research Center of Oncology, Ministry of Health of RussiaФГБУ «НМИЦ онкологии им. Н.Н. Блохина» Минздрава России2411201817222302311201823112018https://bioterapevt.abvpress.ru/jour/article/view/1084

Brain metastases are very common in non-small cell lung cancer. The condition of these patients is complicated and difficult to treat, and adverse reactions following treatment can affect the nervous system, which severely reduces quality of life. In this review we discuss the methods in use from local therapies such as whole brain irradiation, stereotactic radiosurgery and central nervous system surgery to systemic therapy. We also highlight drugs for targeted therapy of non-small lung cancer cells metastasis in the brain that have been effective in the treatment of metastases in central nervous system.

В структуре метастатического поражения головного мозга рак легкого занимает первое место. В обзоре представлены методы лечения метастатического поражения головного мозга при немелкоклеточном раке легкого: от локальных методов лечения (облучение всего головного мозга, стереотаксическая радиохирургия и хирургия опухолей центральной нервной системы) до системной противоопухолевой лекарственной терапии с акцентом на новые таргетные препараты (ингибиторы EGFR), которые показали высокую эффективность при метастазах немелкоклеточного рака легкого в центральную нервную систему.

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