Quinazolinon derivatives for the treatment of neoplastic, parasitic and neurodegenerative diseases

D. S. Khachatryan; Хачатрян Д. С.; V. A. Misyurin; Мисюрин В. А.; M. A. Baryshnikova; Барышникова М. А.; N. V. Golubtsova; Голубцова Н. В.; A. V. Kolotaev; Колотаев А. В.; K. R. Matevosyan; Матевосян К. Р.

doi:10.17650/1726-9784-2017-16-3-32-42

Quinazolinon derivatives for the treatment of neoplastic, parasitic and neurodegenerative diseases

Authors: Khachatryan D.S.¹, Misyurin V.A.², Baryshnikova M.A.¹^,3, Golubtsova N.V.², Kolotaev A.V.¹, Matevosyan K.R.⁴
Affiliations:
1. Institute of Chemical Reagents and High Purity Chemical Substances (IREA)
2. N.N. Blokhin Russian Cancer Research Center, Ministry of Health of Russia
3. N.N. Blokhin Russian Cancer Research Center
4. Dmitry Mendeleev University of Chemical Technology of Russia
Issue: Vol 16, No 3 (2017)
Pages: 32-42
Section: REVIEWS
Published: 30.09.2017
URL: https://bioterapevt.abvpress.ru/jour/article/view/877
DOI: https://doi.org/10.17650/1726-9784-2017-16-3-32-42
ID: 877

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Abstract

In this review we discuss some biological activities of quinazolinon derivatives. The derivatives of quinazolinon possess their activity by binding to some proteins important for the survival, proliferation and metastasis of tumor cells. There are grounds to initiate clinical trials of these substances to create new treatment protocols for a wide range of cancer diseases, several parasitic diseases, and certain neurodegenerative diseases.