Role of tumor-like multipotent mesenchymal stromal cells in rheumatoid arthritis


Cite item

Full Text

Open Access Open Access
Restricted Access Access granted
Restricted Access Subscription or Fee Access

Abstract

Multipotent mesenchymal stromal/stem cells (MSCs) are regarded as a stable, safe and easily available source of precursor cells for purposes of regenerative medicine. However, under repeated replication in tissue reparation processes and action of inflammatory mediators, aged MSCs may be transformed and obtain certain tumor-cell characteristics. The present review deals with the MSCs role in pathogenesis of rheumatoid arthritis. High proliferation speed, lack of contact inhibition and invasive growth of transformed MSCs is an important mechanism of cartilage destruction in rheumatoid arthritis.

About the authors

M. V. Kiselevskiy

N.N. Blokhin Russian Cancer Research Center

Author for correspondence.
Russian Federation

N. Yu. Anisimova

N.N. Blokhin Russian Cancer Research Center

Russian Federation

I. O. Chikileva

N.N. Blokhin Russian Cancer Research Center

Russian Federation

R. Ya. Vlasenko

N.N. Blokhin Russian Cancer Research Center

Russian Federation

Yu. I. Dolzhikova

N.N. Blokhin Russian Cancer Research Center

Russian Federation

S. M. Sitdikova

N.N. Blokhin Russian Cancer Research Center

Email: suriyasitdikova@yandex.ru
Russian Federation

F. S. Senatov

National University of Science and Technology“MISIS”

Russian Federation

K. C. Yang

School of Dental Technology, College of Oral Medicine

Russian Federation

J. C. Yang

Graduate Institute of Nanomedicine and Medical Engineering College of Biomedical Engineering, Taipei Medical University

Russian Federation

References

Supplementary files

Supplementary Files
Action
1. JATS XML

Copyright (c)



СМИ зарегистрировано Федеральной службой по надзору в сфере связи, информационных технологий и массовых коммуникаций (Роскомнадзор).
Регистрационный номер и дата принятия решения о регистрации СМИ: серия ПИ № ФС77-53039 от  04.03.2013.