The effectiveness of combined therapy of dyslipidemia by atorvastatin and biologycally active substances from marine hydrobionts


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Abstract

Introduction. The perspective direction in therapy of dyslipidemia (DLP) is a complex application of biologycally active substances from marine hydrobionts. Objective. The purpose of research - to compare the lipidcorrective action of preparates based on biologically active substances from marine hydrobionts - fukolam and maristim - individually and in combination with atorvastatin in patients with DLP. Materials and methods. 250patients with DLP and 40 healthy donors were included in research. As medicines atorvastatin, fukolam, maristim were used. In the blood serum the levels of lipid spectrum were determined. Results. Hypolipidemic action of fukolam in complex of basic therapy of patients with DLP was implemented by gradually reducing the total cholesterol, cholesterol of low-density lipoproteins, triglycerides levels to control values. The efficacy of fukolam was comparable with that of atorvastatin in a daily dose of 10 mg. Complex of «fukolam-maristim» showed hypolipidemic effect in severe hyperlipidemia. Conclusions. Combined therapy with use of bioactive substances of natural origin may be one of the way to improve the efficiency of hypolipidemic therapy. We have developed the algorithm of differential correction of DLP by inclusion the fukolam and maristim in complex therapy.

About the authors

S. P. Krizshanovsky

Medical Association of Far East Branch of Russian Academy of Science

Author for correspondence.
Russian Federation

B. I. Geltser

Far Eastern Federal University, School of biomedicine

Russian Federation

T. A. Kuznetsova

G.P. Somov Research Institute of Epidemiology and Microbiology

Russian Federation

E. V. Persiyanova

Medical Association of Far East Branch of Russian Academy of Science; G.P. Somov Research Institute of Epidemiology and Microbiology

Email: helen-pers@yandex.ru
Russian Federation

T. S. Zaporozhets

Medical Association of Far East Branch of Russian Academy of Science; G.P. Somov Research Institute of Epidemiology and Microbiology

Russian Federation

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