FUCOIDAN FROM BROWN ALGAE FUCUS EVANESCENS: NEW PERSPECTIVES IN THE TREATMENT OF ATHEROSCLEROSIS


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Abstract

Objective. The purpose of the research is the experimental study of the possibility of correction of disorders of lipid metabolism, lipid peroxidation and antioxidant protection (POL-AOP), liver structure on the model of alimentary hyperlipidemia in mice. Materials and methods. Fucoidan, a sulfated polysaccharide with a molecular weight of 160 kDa, derived from brown algae Fucus evanescens. The alimentary hyperlipidemia model was reproduced in mice. The biochemical parameters of lipid metabolism, state of POL-AOP system and the liver structure by MRT were studied. Results. We revealed the ability of fucoidan at per os administration to animals to normalize the key parameters of lipid metabolism, indicators of POL-AOP system, liver anatomic-topographic structure. Conclusion. The ability of fucoidan to correct these parameters allows us to consider it as a basis for the development of new biological medicines for the treatment of atherosclerotic disorders.

About the authors

S. P. Krizshanovsky

Medical Association of Far East Branch of Russian Academy of Science

Author for correspondence.
Russian Federation

T. A. Kuznetsova

G.P. Somov Research Institute of Epidemiology and Microbiology; Far Eastern Federal University, School of Biomedicine

Email: takuznets@mail.ru
Russian Federation

B. I. Geltser

Far Eastern Federal University, School of Biomedicine

Russian Federation

T. S. Zaporozhets

Medical Association of Far East Branch of Russian Academy of Science; G.P. Somov Research Institute of Epidemiology and Microbiology

Russian Federation

S. P. Ermakova

G.B. Elyakov Pacific Institute of Bioorganic Chemistry

Russian Federation

N. N. Besednova

G.P. Somov Research Institute of Epidemiology and Microbiology

Russian Federation

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