MULTIPHYTOADAPTOGENE ADMINISTRATION IN EARLY POSTNATAL ONTOGENESIS IMPROVE LIFE-SPAN AND PHYSICAL STATUS OF HIGH-CANCER MICE


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Abstract

The aim of this investigation was to evaluate the life-span and physical status (weight, hair character, motor activity) of CBA inbred mice with high frequency of spontaneous hepatocarcinomas using multiphytoadaptogene complex (MPAC) preventive administration in early postnatal ontogenesis. Materials and method. MPAC is a herbal formula composed of forty plants water-ethanol extracts components including adaptogenes Panax ginseng, Eleutheroccosus senticosus, Rhodiola rosea. Anti-tumour, anti-oxidant, anti-mutagenic, immunomodifying activities of MPAC was demonstrated in previous studies. The study was carried out on 131 males of CBA mouse strain. The experimental mice received 10 % MPAC solution in drinking water during the first month of life including the final time period of liver differentiation. Motor activity was determined by a test of the «open field» automatically using Opto-Varimex-3 (Columbus Instruments, USA). The average lifespan was evaluated. Statistical analysis was performed with the program STATISTICA 6.0. Survival median was determined by the Kaplan-Meier method. Results. MPAC preventive use in early postnatal ontogenesis promotes mouse longevity increase for 17,1 % (p < 0,001), longevity median -for 25,6 % (p < 0,001). Physical status of experimental animals using MPAC administration had an advantage over control mice. Conclusion. So, data obtained demonstrate nontoxic MPAC administration in early ontogenesis promotes significant life-span increase, keeps the body weight, good coat state, motor activity as well as prevents hepatocarcinomas formation.

About the authors

E. V. Bocharov

N.N. Blokhin Russian Cancer Research Center, Ministry of Health of Russia

Author for correspondence.
Russian Federation

R. V. Karpova

N.N. Blokhin Russian Cancer Research Center, Ministry of Health of Russia

Russian Federation

O. A. Bocharova

N.N. Blokhin Russian Cancer Research Center, Ministry of Health of Russia

Russian Federation

V. G. Kucheryanu

Institute of general pathology and pathophysiology

Email: planta39@rambler.ru
Russian Federation

Z. S. Shprakh

N.N. Blokhin Russian Cancer Research Center, Ministry of Health of Russia

Russian Federation

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