IMPACT OF TUMOR-DERIVED FACTORS ON DENDRITIC CELLS IN CANCER


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Abstract

Dendritic cells play key role during tumorigenesis and immune response to it. They are able to uptake and present antigens to T cells, resulting in specific T cell mediated immune response. Furthermore, interaction between dendritic cells and other types of immune cells may boost cell-mediated and humoral immune response to cancer. Contrary to that, numerous tumor-derived factors may attract dendritic cells to neoplastic sites, causing impairment of their maturation, differentiation, and functional activity, resulting in deficiency of anti-tumor immune response or dendritic cell-mediated tolerance. Various factors within tumor microenvironment may either stimulate or inhibit dendritic cells and therefore need to be determined for improving efficacy of biotherapy utilizing dendritic cells. Meanwhile, recovery of dendritic cells functions in cancer patients remains one of primary aims for cancer immunotherapy. This review outlines main types of tumor-derived factors and their impact on dendritic cells in cancer.

About the authors

A. A. Keskinov

N.N. Blokhin Russian Cancer Research Center, Ministry of Health of Russia; University of Pittsburgh

Author for correspondence.
Email: a.keskinov@yahoo.com
Russian Federation

M. R. Shurin

University of Pittsburgh

Russian Federation

V. M. Bukhman

N.N. Blokhin Russian Cancer Research Center, Ministry of Health of Russia

Russian Federation

Z. S. Shprakh

N.N. Blokhin Russian Cancer Research Center, Ministry of Health of Russia

Russian Federation

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