Email this article TECHNOLOGICAL APPROACHES TO IMPROVING THE PROCESS LYOPHILIZATION OF PROTEIN AND PEPTIDE DRUGS
- Authors: Blynskaya E.V.1, Tishkov S.V.1, Alekseev K.V.2
-
Affiliations:
- V.V. Zakusov Research Institute of Pharmacology
- Medical University “REAVIZ”
- Issue: Vol 16, No 1 (2017)
- Pages: 6-11
- Section: REVIEWS
- Published: 30.03.2017
- URL: https://bioterapevt.abvpress.ru/jour/article/view/849
- DOI: https://doi.org/10.17650/1726-9784-2017-16-1-6-11
- ID: 849
Cite item
Open Access
Access granted
Subscription or Fee Access
Abstract
Lyophilization of protein and peptide anticancer drugs is a promising method to create a stable and effective parenteral dosage forms. This article reviews the main problems encountered during lyophilization of protein and peptide drugs, and describes the best practices for solving these problems. The ways of optimization and improvement of the freeze-drying are given. Temperatures to improve the properties and prevent the destruction of the cake lyophilizatiе are suggested.
About the authors
E. V. Blynskaya
V.V. Zakusov Research Institute of Pharmacology
Author for correspondence.
Email: eaureus@mail.ru
Russian Federation
S. V. Tishkov
V.V. Zakusov Research Institute of PharmacologyRussian Federation
K. V. Alekseev
Medical University “REAVIZ”Russian Federation
References
Supplementary files
