POTENTIAL ANTITUMOR ACTIVITY STUDIES ON SOME COORDINATION COMPOUNDS OF RARE EARTH ELEMENTS WITH ANTIPYRINE

I. S. Golubeva; Голубева Ирина Сергеевна; N. P. Yavorskaya; Яворская Н. П.; M. A. Baryshnikova; Барышникова М. А.; D. A. Afanasieva; Афанасьева Д. А.; A. A. Rudakova; Рудакова А. А.; G. N. Apryshko; Апрышко Г. Н.; N. S. Rukk; Рукк Н. С.; A. Yu. Skraybina; Скрябина А. Ю.

doi:10.17650/1726-9784-2016-15-4-89-95

POTENTIAL ANTITUMOR ACTIVITY STUDIES ON SOME COORDINATION COMPOUNDS OF RARE EARTH ELEMENTS WITH ANTIPYRINE

Authors: Golubeva I.S.¹, Yavorskaya N.P.¹, Baryshnikova M.A.¹, Afanasieva D.A.¹, Rudakova A.A.¹, Apryshko G.N.¹, Rukk N.S.², Skraybina A.Y.²
Affiliations:
1. ФГБУ «Российский онкологический научный центр им. Н.Н. Блохина» Минздрава России
2. ФГБОУ ВО «Московский технологический университет» (МИТХТ)
Issue: Vol 15, No 4 (2016)
Pages: 89-95
Section: ORIGINAL REPORTS
Published: 30.12.2016
URL: https://bioterapevt.abvpress.ru/jour/article/view/844
DOI: https://doi.org/10.17650/1726-9784-2016-15-4-89-95
ID: 844

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Abstract

The aim of this study was to examine the anticancer activity of rare earth elements complexes with antipirin. Materials and methods. We have studied the cytotixic activity of in vitro and antineoplastic activity in vivo of 28 iodides and perchlorates containing as a ligand antipirine. Results. Here we show, that non of tested compounds exert cytotoxic action on 5 human cancer cell lines of different histogenesis at a concentration of 100 ßM. However, we observe that two complexes of antipirine derivatives with iodides of gadolinium and neodymium possess anti-tumor activity in experiments with transplantable solid tumors. Conclusion. The data obtained indicate the feasibility of further studies of these two complexes on a larger number of mice, with changing doses and routes of administration. We also suggest the investigation of these compounds on ascites tumors.

Keywords

комплексы лантаноидов с антипирином, цитотоксичность, противоопухолевая активность, lanthanide complexes with antipyrine, cytotoxicity, antitumor activity

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POTENTIAL ANTITUMOR ACTIVITY STUDIES ON SOME COORDINATION COMPOUNDS OF RARE EARTH ELEMENTS WITH ANTIPYRINE

Full Text

Abstract

Keywords

About the authors

References

Supplementary files