REDOX DENDRIMERS

Yu. V. Stukalov; Стукалов Ю. В.; E. Yu. Grigorieva; Григорьева Елена Юрьевна; N. S. Kalygina; Калыгина Н. С.; E. Yu. Koldaeva; Колдаева Е. Ю.; A. S. Masko; Масько А. С.

doi:10.17650/1726-9784-2016-15-4-40-43

REDOX DENDRIMERS

Authors: Stukalov Y.V.¹, Grigorieva E.Y.¹, Kalygina N.S.¹, Koldaeva E.Y.¹, Masko A.S.¹
Affiliations:
1. ФГБУ «Российский онкологический научный центр им. Н.Н. Блохина» Минздрава России
Issue: Vol 15, No 4 (2016)
Pages: 40-43
Section: BRIEF REPORT
Published: 30.12.2016
URL: https://bioterapevt.abvpress.ru/jour/article/view/835
DOI: https://doi.org/10.17650/1726-9784-2016-15-4-40-43
ID: 835

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Abstract

Aim of this work was the synthesis of REDOX-dendrimer core, which is tetraglycidyl ether of pentaerythritol, and a dendron, which is a derivative of anthraquinone. Materials and methods. Analytical and preparative chromatography was carried out on a liquid chromatograph SP 8000 (Spectra-Physics (USA)). Chromatograms were recorded using a UV-detector (Spectra-Physics (USA)) and refractive index detector (Jobin-Ivon (France)). The structure was confirmed by PMR (Bruker WH-360 (Germany)) with an operating frequency of 360 MHz. Monitoring of reactions conducted using HPLC. Results. Derivatives of 2-methylanthraquinone were synthesized and isolated by use of preparative HPLC. Their structure was determined by PMR-spectroscopy. They were used as a dendron in the synthesis of dendrimer. Its toxicity was studied in male mice ВDF1. Redox dendrimers containing methylanthraquinone derivatives in its structure were synthetized. Low toxicity of obtained REDOX-dendrimer was shown. Conclusion. The similarity of REDOX-dendrimer structure with doxorubicin and its low toxicity provides background for further study of its antitumor activity.

Keywords

REDOX-дендример, производные 2-метилантрахинона, тетраглицидиловый эфир пентаэритрита, высокоэффективная жидкостная хроматография, токсикология, REDOX-dendrimer, derivatives 2-methylanthraquinone, tetraglycidyl ether of pentaerythritol, HPLC, toxicology

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REDOX DENDRIMERS

Full Text

Abstract

Keywords

About the authors

Yu. V. Stukalov

E. Yu. Grigorieva

N. S. Kalygina

E. Yu. Koldaeva

A. S. Masko

References

Supplementary files