ESSENTIALS OF THE MOLECuLAR DIAGNOSIS OF ONCOHEMATOLOGICAL DISEASES

Molecular genetic and molecular biology methods enable one to reveal pathogenetic basis of oncohematological diseases, they are particular useful for diagnostic purpouses, to control and evaluate treatment efficiency. In leukemia patients there are two different types of chromosomal anomalities: some of them give rise for chimeric oncogenes, others activate hyperexpression of regulatory genes. It is necessary to take into account this difference in order to proparely develop molecular genetic tests. Molecular tests are more sensitive to compare with other approaches, due to this fact they are especially useful to monitor residual leukemia cells and for early detection of relapse.

полимеразная цепная реакция с обратной транскрипцией, полимеразная цепная реакция в реальном времени, транслокация, химерный онкоген, минимальная остаточная болезнь, лейкемия, polymerase chain reaction with reverse transcription, real-time polymerase chain reaction, translocation, chimeric oncogene, minimal residual disease, leukemia