THE PREPARATION FOR INTRAOPERATIVE VISUALIZATION OF «SENTINEL» LYMPH NODES


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Abstract

We developed the original preparation Lymphotest on the basis of disulphoderivative of diaminotriphenylmet- anic dye, differing from Lymphazurin by positions if sulphogroups in benzene ring - N-[4-[[4-(diethylamino)phenyl] (2,5-disulfophenyl)methylene]-2,5-cyclohexadien-l-ylidene]-N-ethylethanaminium hydroxide, inner salt, sodium salt. The proposed compound practically does not differ by spectrum from Lymphazurin, but is much more accessible and highly lymphotropic. Lymphotest in the form of 1% aqueous solution is characterized by a high diagnostic efficiency when using direct color lymphography, low toxicity (imposed dose exceeded the anticipated maximum dose for a human in 50-1000 times) and has no locally-irritating effect when using subcutaneously.

About the authors

A. A. Pankratov

Hertsen Moscow Research Institute of Oncology

Author for correspondence.
Russian Federation

T. N. Andreeva

Hertsen Moscow Research Institute of Oncology

Russian Federation

R. I. Yakubovskaya

Hertsen Moscow Research Institute of Oncology

Russian Federation

A. D. Kaprin

Hertsen Moscow Research Institute of Oncology

Russian Federation

A. A. Konarev

State Research Center «NIOPIK»

Russian Federation

T. V. Yakunina

State Research Center «NIOPIK»

Russian Federation

E. A. Lukyanets

State Research Center «NIOPIK»

Russian Federation

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