INFLUENCE OF A POSITIVE CHARGE IN THE STRUCTURE OF PHOTOSENSITIZERS OF CHLORIN SERIES ON THE PHOTOINDUCED ANTICANCER ACTIVITY


Cite item

Full Text

Open Access Open Access
Restricted Access Access granted
Restricted Access Subscription or Fee Access

Abstract

A neutral photosensitizer, aminobutylamide chlorin e6 with a terminal amino group (1), and its derivative, a cationic photosensitizer with a terminal trimethylammonium group (2) were synthesized. Spectral, photophysical and photobiological properties of compounds 1 and 2 were studied. An impact of a charge in molecule 2 on a photoinduced antitumor activity was evaluated in vitro. Relative coefficients of intracellular accumulation (Krei) were determined for compounds 1 and 2 in human lung adenocarcinoma A549 and human glioblastoma U251 cells. The coefficients of intracellular accumulation of neutral chlorin 1 in both cell types are fivefold higher than those of cationic chlorin 2. As a consequence, compound 1 surpasses fifteen-fold compound 2 in photoinduced cytotoxicity.

About the authors

S. S. Brusov

Moscow State University of Fine Chemical Technologies named after M.V. Lomonosov

Author for correspondence.
Russian Federation

A. V. Efremenko

Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences; M.V. Lomonosov Moscow State University

Russian Federation

V. S. Lebedeva

Moscow State University of Fine Chemical Technologies named after M.V. Lomonosov

Russian Federation

E. Yu. Shchepelina

Moscow State University of Fine Chemical Technologies named after M.V. Lomonosov

Russian Federation

Ph. V. Ponomarev

Moscow State University of Fine Chemical Technologies named after M.V. Lomonosov

Russian Federation

A. V. Feofanov

Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences; M.V. Lomonosov Moscow State University

Russian Federation

A. F. Mironov

Moscow State University of Fine Chemical Technologies named after M.V. Lomonosov

Russian Federation

M. A. Grin

Moscow State University of Fine Chemical Technologies named after M.V. Lomonosov

Email: michaelgrin@mail.ru
Russian Federation

References

Supplementary files

Supplementary Files
Action
1. JATS XML

Copyright (c)



СМИ зарегистрировано Федеральной службой по надзору в сфере связи, информационных технологий и массовых коммуникаций (Роскомнадзор).
Регистрационный номер и дата принятия решения о регистрации СМИ: серия ПИ № ФС77-53039 от  04.03.2013.