THE COMBINED METHOD OF EFFECT PHOTODYNAMIC THERAPY AND RADIAL THERAPY ON SARCOMA М-1 OF RATS


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Abstract

Antitumoral therapy of sarcoma M-l of rats is spent with use of the combined method of treatment (photodynamic therapy and radial therapy) at various sequences of its carrying out, at different time intervals and parametres of a laser irradiation. A photosensitinogen dose amidoaminchlorine and a gamma radiation dose were identical at all spent researches. The purpose: to study influence of all components of combined therapy and to define optimum conditions of its carrying out for achievement of significant antitumoral effect in comparison with monotherapy of each of them. As a result of researches intensifying of inhibiting effect is taped at complex therapy and optimum parametres of its carrying out are found.

About the authors

M. A. Kaplan

A. Tsyb Medical Radiological Research Centre - branch of the National Medical Research Radiological Centre of the Ministry of Health of the Russian Federation

Author for correspondence.
Email: kaplan@mrrc.obninsk.ru
Russian Federation

A. I. Malygina

A. Tsyb Medical Radiological Research Centre - branch of the National Medical Research Radiological Centre of the Ministry of Health of the Russian Federation

Russian Federation

G. V. Ponomarev

Institute of biomedical chemistry of the Russian Academy of Medical Science

Russian Federation

A. A. Mikhailovskaya

A. Tsyb Medical Radiological Research Centre - branch of the National Medical Research Radiological Centre of the Ministry of Health of the Russian Federation

Russian Federation

V. V. Drozhzhina

A. Tsyb Medical Radiological Research Centre - branch of the National Medical Research Radiological Centre of the Ministry of Health of the Russian Federation

Russian Federation

L. M. Arkhipova

A. Tsyb Medical Radiological Research Centre - branch of the National Medical Research Radiological Centre of the Ministry of Health of the Russian Federation

Russian Federation

J. S. Osipchuk

A. Tsyb Medical Radiological Research Centre - branch of the National Medical Research Radiological Centre of the Ministry of Health of the Russian Federation

Russian Federation

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