NONCLINICAL STUDY OF THE TOXICITY OF A NEW ANTICANCER DRUG ОRMUSTIN ON SMALL LABORATORY ANIMALS


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Abstract

The paper presents the results of the study of «acute» toxicity and some results of the study of «subchronic» toxicity of Ormustin, a new anticancer drug belonging to nitrosourea class, in small laboratory animals. In the experiments the laboratory animals - hybrid mice (C57Bl/6J×DBA/2)F1 male and female and outbred male and female rats have been used. On the results of study has been obtained the calculated toxic doses of Ormustin at intravenous administration of the drug in mice and rats; has been given the preliminary assessment of the impact of Ormustin on organs and systems of rats at multiple intravenous administration.

About the authors

V. A. Chaley

FSBI «N.N. Blokhin Russian Cancer Research Center», MH RF

Author for correspondence.
Russian Federation

O. I. Konyaeva

FSBI «N.N. Blokhin Russian Cancer Research Center», MH RF

Russian Federation

N. P. Ermakova

FSBI «N.N. Blokhin Russian Cancer Research Center», MH RF

Russian Federation

A. A. Nikolina

FSBI «N.N. Blokhin Russian Cancer Research Center», MH RF

Russian Federation

V. M. Bukhman

FSBI «N.N. Blokhin Russian Cancer Research Center», MH RF

Russian Federation

N. Yu. Kul’Bachevskaya

FSBI «N.N. Blokhin Russian Cancer Research Center», MH RF

Russian Federation

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