STUDY OF ACUTE TOXICITY OF NOVEL ANTITUMOR PREPARATION BASED ON DERIVATIVE OF INDOLOCARBAZOLE - LCS-1208


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Abstract

The research has been devoted to the study of acute toxicity of preparation based on derivative of indolocarba- zole - LCS-1208 in mice of both sexes and in rats of both sexes at intravenous and intraperitoneal administration of the drug. In the experiments the laboratory animals - outbred white rats and hybrid mice (C57Bl/6JxDBA2)Fl (B6D2F1) have been used. On the results of study has been obtained the calculated toxic doses of novel preparation based on derivative of indolocarbazole at intraperitoneal administration of the drug in mice of both sexes.

About the authors

A. A. Nikolina

FSBI «N.N. Blokhin Russian Cancer Research Center» of the Ministry of Health of the Russian Federation

Author for correspondence.
Email: osipova.alio@va.ru
Russian Federation

N. Ju. Kul'bachevskaja

FSBI «N.N. Blokhin Russian Cancer Research Center» of the Ministry of Health of the Russian Federation

Russian Federation

O. I. Konjaeva

FSBI «N.N. Blokhin Russian Cancer Research Center» of the Ministry of Health of the Russian Federation

Russian Federation

V. A. Chalej

FSBI «N.N. Blokhin Russian Cancer Research Center» of the Ministry of Health of the Russian Federation

Russian Federation

N. P. Ermakova

FSBI «N.N. Blokhin Russian Cancer Research Center» of the Ministry of Health of the Russian Federation

Russian Federation

V. M. Bukhman

FSBI «N.N. Blokhin Russian Cancer Research Center» of the Ministry of Health of the Russian Federation

Russian Federation

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