THE LIPOSOMAL ARANOSA DOES NOT INDUCE AUTOPHAGY

D. A. Afanasieva; Афанасьева Д. А.; M. A. Baryshnikova; Барышникова Мария Анатольевна; Yu. A. Khochenkova; Хоченкова Ю. А.; P. V. Golyshko; Голышко П. В.; D. A. Khochenkov; Хоченков Д. А.; E. V. Stepanova; Степанова Е. В.; O. O. Ryabaya; Рябая О. О.

doi:10.17650/1726-9784-2015-14-1-15-18

THE LIPOSOMAL ARANOSA DOES NOT INDUCE AUTOPHAGY

Authors: Afanasieva D.A.¹, Baryshnikova M.A.¹, Khochenkova Y.A.¹, Golyshko P.V.¹, Khochenkov D.A.¹, Stepanova E.V.¹, Ryabaya O.O.¹
Affiliations:
1. FSBSI «N.N. Blokhin Russian Cancer Research Center»
Issue: Vol 14, No 1 (2015)
Pages: 15-18
Section: ORIGINAL REPORTS
Published: 30.03.2015
URL: https://bioterapevt.abvpress.ru/jour/article/view/4
DOI: https://doi.org/10.17650/1726-9784-2015-14-1-15-18
ID: 4

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Abstract

Previous studies have shown that aranosa-lio initiate cell death by activation of CD95-receptor of apoptosis. The mechanism of liposomal aranosa action is still unknown. Anticancer drugs may cause tumor cell death by the activation of autophagy. The purpose of this study was to determine the influence of liposomal aranosa on autophagy. The study was assessed on human melanoma cell lines mel Mtp, mel Ibr, mel Kor, mel Z and mel Mtp clone X. The cells were treated with aranosa-lio or liposomal aranosa at concentration 450 μg/ml for 24 hours. The expression of autophagy were analyzed the expression of mRNA Beclin 1. Expression of mRNA Beclin 1 was reduced on the majority of cell lines, which might be due to the fact that the liposomal form of the drug caused cell death by intrinsic apoptosis which is suppose to suppress autophagy.

Keywords

араноза, липосомы, аутофагия, клеточная гибель, aranosa, liposomes, autophagy, cell death

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THE LIPOSOMAL ARANOSA DOES NOT INDUCE AUTOPHAGY

Full Text

Abstract

Keywords

About the authors

D. A. Afanasieva

M. A. Baryshnikova

Yu. A. Khochenkova

P. V. Golyshko

D. A. Khochenkov

E. V. Stepanova

O. O. Ryabaya

References

Supplementary files