Email this article THE ROLE OF EPITHELIAL-MESENCHYMAL TRANSITION IN REGULATION OF SOLID TUMORS CANCER STEM CELLS CHARACTERISTICS
- Authors: Farmakovskaya M.D.1, Khromova N.V.1, Rybko V.A.1, Kopnin P.B.1
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Affiliations:
- FSBI «N.N. Blokhin Russian Cancer Research Center» MH
- Issue: Vol 14, No 4 (2015)
- Pages: 3-8
- Section: REVIEWS
- Published: 30.12.2015
- URL: https://bioterapevt.abvpress.ru/jour/article/view/37
- DOI: https://doi.org/10.17650/1726-9784-2015-14-4-3-8
- ID: 37
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Abstract
CSCs are a tumor cell subpopulation that is a potential cause of cancer therapy resistance, recurrence and metastasis. This is the reason cscs seem a promising target for developing new approaches in anticancer treatment. Several mechanisms have been revealed that allow cancer cells to acquire CSC phenotype making malignant tumor treatment much more complicated. One of such mechanisms is a variant of epithelial-to-mesenchymal transition and e-cadherin loss, which results in cells with CSC characteristics occurring in carcinomas. The purpose of the present study is to review possible ways if cscs formation in human carcinomas.
About the authors
M. D. Farmakovskaya
FSBI «N.N. Blokhin Russian Cancer Research Center» MH
Author for correspondence.
Russian Federation
N. V. Khromova
FSBI «N.N. Blokhin Russian Cancer Research Center» MHRussian Federation
V. A. Rybko
FSBI «N.N. Blokhin Russian Cancer Research Center» MHRussian Federation
P. B. Kopnin
FSBI «N.N. Blokhin Russian Cancer Research Center» MH
Email: pbkotmin@mail.ru
Russian Federation
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