LIPOSOMAL PHOTOSENSITIZER AMIDOAMINCHLORINE FOR PHOTODYNAMIC THERAPY OF RAT SARCOMA М-1


Cite item

Full Text

Abstract

Effectiveness of a new photosensitizer (PS) liposomal amidoaminchlorine for PDT was studied on a tumor model of rat sarcoma М-1. The research objective: to define parameters of PS minimum effective dose and laser irradiation to achieve complete regression of the tumor. Dynamics of PS accumulation in tumor and healthy tissue was studied to define the PDT time course and antitumor efficiency of different PS doses and various parameters of laser irradiation. The study results defined the optimum term for PDT and minimally effective PS dose and established the parameters for laser irradiation.

About the authors

M. A. Kaplan

A.F. Tsyb Medical Radiological Center of Science

Author for correspondence.
Email: kaplan@mrrc.obninsk.ru
Russian Federation

A. I. Malygina

A.F. Tsyb Medical Radiological Center of Science

Russian Federation

G. V. Ponomarev

V.N.Orehovich Institute of biomedical chemistry

Russian Federation

A. A. Mikhailovskaya

A.F. Tsyb Medical Radiological Center of Science

Russian Federation

V. V. Drozhzhina

A.F. Tsyb Medical Radiological Center of Science

Russian Federation

L. M. Arkhipova

A.F. Tsyb Medical Radiological Center of Science

Russian Federation

J. S. Osipchuk

A.F. Tsyb Medical Radiological Center of Science

Russian Federation

References

Supplementary files

Supplementary Files
Action
1. JATS XML
Download

Copyright (c)


СМИ зарегистрировано Федеральной службой по надзору в сфере связи, информационных технологий и массовых коммуникаций (Роскомнадзор).
Регистрационный номер и дата принятия решения о регистрации СМИ: серия ПИ № ФС77-53039 от  04.03.2013.