CURRENT UNDERSTANDING OF ANTITUMOR IMMUNITY

I. Zh. Shubina; Шубина Ирина Жановна; A. V. Sergeev; Сергеев А. В.; L. T. Mamedova; Мамедова Л. Т.; N. Yu. Sokolov; Соколов Н. Ю.; M. V. Kiselevsky; Киселевский М. В.

doi:10.17650/1726-9784-2015-14-3-19-28

CURRENT UNDERSTANDING OF ANTITUMOR IMMUNITY

Authors: Shubina I.Z.¹, Sergeev A.V.¹, Mamedova L.T.¹, Sokolov N.Y.², Kiselevsky M.V.¹
Affiliations:
1. FSBI «N.N. Blokhin RCRC»
2. Central Clinical Hospital
Issue: Vol 14, No 3 (2015)
Pages: 19-28
Section: REVIEWS
Published: 30.09.2015
URL: https://bioterapevt.abvpress.ru/jour/article/view/29
DOI: https://doi.org/10.17650/1726-9784-2015-14-3-19-28
ID: 29

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Abstract

The review presents analysis of the papers that discuss mechanisms of antitumor immunity. The role of innate and adaptive immune reactions as well as local and systemic is considered in terms of immune defense in clinical and experimental studies. The article discusses characteristics and role tumor-associated antigens for clinical practice. Various types of immune effector cells, including T-cells, NK-cell, DC, tumor associated macrophages, etc., and cytokines, are discussed regarding their contribution into antitumor immune response. The authors also refer to the hypothesis of “immunoediting” and its part in antitumor immunity.

Keywords

противоопухолевый иммунитет, иммунокомпетентные клетки, иммуноредактирование, antitumor immunity, immune effector cells, immunoediting

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CURRENT UNDERSTANDING OF ANTITUMOR IMMUNITY

Full Text

Abstract

Keywords

About the authors

I. Zh. Shubina

A. V. Sergeev

L. T. Mamedova

N. Yu. Sokolov

M. V. Kiselevsky

References

Supplementary files