THE BIOLOGICAL ACTIVITY OF PLANT-DERIVED ANTI-HER2 RECOMBINANT ANTIBODIES

V. S. Kosorukov; Косоруков Вячеслав Станиславович; E. N. Kosobokova; Кособокова Е. Н.; M. V. Pinyugina; Пинюгина М. В.; M. A. Sevostyanova; Севостьянова М. А.; A. I. Scherbakov; Щербаков А. И.; N. V. Andronova; Андоронова Н. В.; E. Sh. Solomko; Соломко Э. Ш.; E. V. Sheshukova; Шешукова Е. В.; E. M. Treschalina; Трещалина Е. М.; Yu. L. Dorokhov; Дорохов Ю. Л.

doi:10.17650/1726-9784-2015-14-2-105-112

THE BIOLOGICAL ACTIVITY OF PLANT-DERIVED ANTI-HER2 RECOMBINANT ANTIBODIES

Authors: Kosorukov V.S.¹, Kosobokova E.N.¹, Pinyugina M.V.¹, Sevostyanova M.A.¹, Scherbakov A.I.¹, Andronova N.V.¹, Solomko E.S.¹, Sheshukova E.V.², Treschalina E.M.¹, Dorokhov Y.L.²
Affiliations:
1. ФГБУ «РОНЦ им. Н.Н.Блохина»
2. Московский государственный университет им. М.В. Ломоносова
Issue: Vol 14, No 2 (2015)
Pages: 105-112
Section: ORIGINAL REPORTS
Published: 30.06.2015
URL: https://bioterapevt.abvpress.ru/jour/article/view/26
DOI: https://doi.org/10.17650/1726-9784-2015-14-2-105-112
ID: 26

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Abstract

Pharmaceuticals derived from plants, have become one of the leading commercial directions in modern biotechnology. The benefits that offer these technologies, cannot be matched with any other modern technology for producing drugs from recombinant proteins. Main advantages of plant technologies for production of proteins are easy scalability, efficiency, bio-safety, ease of cultivation and collection of biological material. This approach promises to be the most perspective for production of a wide range of drug substances and vaccines. In current investigation we have analyzed in vitro and in vivo biological activity of plant-derived anti-HER2 recombinant antibodies - phytotrastuzumab. Phytotrastuzumab and trastuzumab have similar activity in grows suppression of breast cancer cells overexpressing HER2 in-vitro and were active in suppression of xenografted tumors SK-BR-3 in-vivo.

Keywords

HER2, рак молочной железы, рекомбинантные антитела, экспрессия в растениях, HER2, breast cancer, recombinant antibodies, plant-derived proteins

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THE BIOLOGICAL ACTIVITY OF PLANT-DERIVED ANTI-HER2 RECOMBINANT ANTIBODIES

Full Text

Abstract

Keywords

About the authors

References

Supplementary files