Email this article SUPPRESSION OF GLIOBLASTOMA CELLULAR TRANSPORTERS SENSITIZES TARGET CELLS TO INFECTION WITH ONCOLYTIC VIRUS IN THE PRESENCE OF IONIZING RADIATION
- Authors: Ulasov I.V.1,2, Kaverina N.V.2, Kadagidze Z.G.2, Baryshnikov A.Y.2
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Affiliations:
- Центр опухолей головного мозга, Шведский медицинский центр
- ФГБНУ «РОНЦ им Н.Н. Блохина»
- Issue: Vol 14, No 2 (2015)
- Pages: 65-70
- Section: ORIGINAL REPORTS
- Published: 30.06.2015
- URL: https://bioterapevt.abvpress.ru/jour/article/view/20
- DOI: https://doi.org/10.17650/1726-9784-2015-14-2-65-70
- ID: 20
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Abstract
It is already established that verapamil inhibits Pgp expression in the brain tumor cancer cells such as medulloblastoma. The aim of this study is to investigate the sensitivity of glioblastoma cancer cells to verapamil and its combination with oncolytic adenoviral victor CRAd-S-pK7. In vitro using U87 and U251 human glioblastoma cell lines, we obtained experimental data suggesting a therapeutic effect of verapamil and CRAd-S-pK7. Moreover, we established that verapamil improves anti-glioma effect of oncolytic adenoviral vector in the presence of ionizing radiation, which results into more suppression of U251 cancer cells via inhibition of their proliferation.
About the authors
I. V. Ulasov
Центр опухолей головного мозга, Шведский медицинский центр; ФГБНУ «РОНЦ им Н.Н. Блохина»
Author for correspondence.
Email: ulasov75@yahoo.com
Russian Federation
N. V. Kaverina
ФГБНУ «РОНЦ им Н.Н. Блохина»Russian Federation
Z. G. Kadagidze
ФГБНУ «РОНЦ им Н.Н. Блохина»Russian Federation
A. Yu. Baryshnikov
ФГБНУ «РОНЦ им Н.Н. Блохина»Russian Federation
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