MOLECULAR MECHANISMS OF MULTIDRUG RESISTANCE OVERCOMING BY LIPOSOMAL ANTITUMOR DRUGS

The liposomal antitumor drugs cell death induction mechanism has been analyzed in this work. Liposomal dosage forms of doxorubicin, cisplatin and aranosa overcome drug resistance. However, the mechanism of overcoming drug resistance by this drugs is different. Liposomal doxorubicin overcomes multidrug resistance by liposomes binding with the P-glycoprotein in 185 position of glycine. Liposomal cisplatin overcomes monoresistance by external apoptosis gene activation. The liposomal aranosa does not use CD95/Fas signaling pathway of apoptosis. Thus, liposomal drug action mechanism depends on the type of cells, and on the antitumor drug, that is enclosed in a liposome and can be individualized in each case.

множественная лекарственная устойчивость, противоопухолевые препараты, липосомы, multidrug resistance, antitumor drugs, liposomes