ROLE OF ESTROGEN RECEPTOR BETA IN THE DEVELOPMENT AND TREATMENT OF BREAST CANCER

M. V. Rodionova; Родионова Мария Валерьевна; I. K. Vorotnikov; Воротников И. К.; V. V. Rodionov; Родионов В. В.; N. V. Chkhivadze; Чхиквадзе Н. В.; E. A. Dudko; Дудко Е. А.; D. A. Ryabchikov; Рябчиков Д. А.; E. V. Oshkina; Ошкина Е. В.; T. A. Bogush; Богуш Т. А.

doi:10.17650/1726-9784-2015-14-2-39-46

ROLE OF ESTROGEN RECEPTOR BETA IN THE DEVELOPMENT AND TREATMENT OF BREAST CANCER

Authors: Rodionova M.V.¹, Vorotnikov I.K.¹, Rodionov V.V.², Chkhivadze N.V.¹, Dudko E.A.¹, Ryabchikov D.A.¹, Oshkina E.V.¹, Bogush T.A.¹
Affiliations:
1. ФГБУ «Российский онкологический научный центр им. Н.Н. Блохина»
2. Ульяновский государственный университет
Issue: Vol 14, No 2 (2015)
Pages: 39-46
Section: REVIEWS
Published: 30.06.2015
URL: https://bioterapevt.abvpress.ru/jour/article/view/16
DOI: https://doi.org/10.17650/1726-9784-2015-14-2-39-46
ID: 16

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Abstract

Estrogen receptors are one of the major targets in cancer cells, acting on which it is possible not only to control the processes of carcinogenesis, but also to inhibit tumor cells growth. Brilliant confirmation of this is the results of long-term application of the first targeted therapy - antiestrogen tamoxifen - in breast cancer patients with positive hormonal status of the tumor. Being discovered in the 90s, estrogen receptor beta enhanced the understanding of estrogen-mediated signaling pathway and receptor-related interactions. This review of the literature presents data on the history of the discovery, structure and functional activity of selective estrogen receptor beta, and the results of existing clinical trials which have shown the predictive role of this marker.

Keywords

рак молочной железы, эстрогеновые рецепторы, тамоксифен, предиктивный маркер, breast cancer, estrogen receptors, tamoxifen, predictive biomarker

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ROLE OF ESTROGEN RECEPTOR BETA IN THE DEVELOPMENT AND TREATMENT OF BREAST CANCER

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Abstract

Keywords

About the authors

References

Supplementary files