AURUM POLYACRYLATE: THE EXPERIMENTAL STUDY OF THE ANTITUMOR ACTIVITY

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Abstract

Introduction. The investigation of metal substituted organic compounds as potential antitumor drugs is one of the promising areas of research in experimental and clinical oncology.

Objective. The pre-clinical study of the original antitumor drug aurum polyacrylate (aurumacryl) which belongs to such new for oncology group of compounds as polyacrylates of metals was the aim of this work.

Materials and methods.  Aurumacryl antitumor activity was determined as the tumor growth inhibitory effect against some of the murine solid tumors (Lewis lung carcinoma, Acatol adenocarcinoma and Ca-755 adenocarcinoma). Drug cytotoxic effect against some of the human tumor cells (Mel-Mo melanoma, A549 lung carcinoma, MCF-7 breast carcinoma, HCT116 colon adenocarcinoma) was evaluated with standard МТТ-test. The aurumacryl pharmacokinetics in tumor bearing mice (Lewis lung carcinoma) was studied. The inductively coupled plasma mass spectrometry method was used for the estimation of the aurum maintenance in the tested tissues (tumor, blood, kidneys, liver, lungs, spleen, brain).

Results. The 80–90 % tumor growth inhibitory effect of aurumacryl against some solid tumors in mice had been revealed in vivo as well as the death of the 60–90 % human tumor cells of various origins in vitro. Beside this the strong decrease of the number of proliferating MCF-7 tumor cells had been shown. The distribution of aurumacryl in the body of the mice with the solid tumor had been revealed.

Conclusion. On the base of the data obtained the further study of the aurumacryl as a potential antitumor agent seems rather promising.

About the authors

L. A. Ostrovskaya

N.M. Emanuel Institute of Biochemical Physics, Russian Academy of Sciences

Author for correspondence.
Email: larros@list.ru
ORCID iD: 0000-0002-9484-5578
4 Kosigin St., Moscow 119991 Russian Federation

D. B. Korman

N.M. Emanuel Institute of Biochemical Physics, Russian Academy of Sciences

ORCID iD: 0000-0002-8890-1924
4 Kosigin St., Moscow 119991 Russian Federation

N. V. Bluhterova

N.M. Emanuel Institute of Biochemical Physics, Russian Academy of Sciences

ORCID iD: 0000-0002-3295-6950
4 Kosigin St., Moscow 119991 Russian Federation

M. M. Fomina

N.M. Emanuel Institute of Biochemical Physics, Russian Academy of Sciences

ORCID iD: 0000-0002-5202-5088
4 Kosigin St., Moscow 119991 Russian Federation

V. A. Rikova

N.M. Emanuel Institute of Biochemical Physics, Russian Academy of Sciences

ORCID iD: 0000-0001-6163-2923
4 Kosigin St., Moscow 119991 Russian Federation

A. K. Chigasova

N.M. Emanuel Institute of Biochemical Physics, Russian Academy of Sciences

ORCID iD: 0000-0001-7288-7155
4 Kosigin St., Moscow 119991 Russian Federation

E. I. Nekrasova

N.M. Emanuel Institute of Biochemical Physics, Russian Academy of Sciences

ORCID iD: 0000-0002-1703-5010
4 Kosigin St., Moscow 119991 Russian Federation

K. A. Abzaeva

A.E. Favorsky Irkutsk Institute of Chemistry, Siberian Branch of the Russian Academy of Sciences

ORCID iD: 0000-0001-5659-7078
1 Favorsky St., Irkutsk 664033 Russian Federation

O. O. Riabaya

N.N. Blokhin National Medical Research Center of Oncology of the Ministry of Health of Russia

ORCID iD: 0000-0001-6295-3497
24 Kashirskoe Shosse, Moscow 115478 Russian Federation

J. P. Burmiy

Institute of Microelectronic Technology and Ultra-High-Purity Materials Russian Academy of Sciences

ORCID iD: 0000-0003-4195-9392
6 Academician Osipian St., Chernogolovka 142432 Russian Federation

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