SPECIAL ASPECTS OF THE TECHNOLOGY OF MEDICATED CHEWING GUM PRODUCTION

Cover Page

Cite item

Full Text

Abstract

Chewing gum medicines are solid dosage forms intended for chewing for a certain period of time without subsequent ingestion to provide local and systemic effects. This article describes the basic technologies for producing chewing gum medicinal products, analyzes and compares the technological aspects of production. In addition, the advantages and disadvantages of the various technologies used, the features of the use in pharmaceutical technology, as well as additional technological methods for creating modifications of the release of drugs from chewing gum medicinal gums are given. It is concluded that the application of various technologies for the production of chewing gums and the methods for improving individual stages of the process are promising.

About the authors

E. V. Blynskaya

Research Zakusov Institute of Pharmacology

Russian Federation

S. V. Tishkov

Research Zakusov Institute of Pharmacology

Author for correspondence.
Email: sergey-tishkov@ya.ru
ORCID iD: 0000-0002-8321-6952
Сергей Валерьевич Тишков Russian Federation

K. V. Alekseev

Research Zakusov Institute of Pharmacology;
“Reaviz” Medical University

Russian Federation

V. V. Bueva

Research Zakusov Institute of Pharmacology

Russian Federation

A. A. Ivanov

Research Zakusov Institute of Pharmacology

Russian Federation

References

  1. Blynskaya E.V., Tishkov S.V., Alekseev K.V. et al Application of dispersion analysis with the purpose of selecting subsidiary substances for obtaining lyophylized GK-2 tablets. Vestnik VGU. Seriya Himiya. Biologiya. Farmaciya = Proceedings of Voronezh State University. Series: Chemistry. Biology. Pharmacy 2019;1:117–26. (In Russ.).
  2. Blynskaya E.V., Tishkov S.V., Alekseev K.V. et al. Features of the design of freeze-dried orally disintegrating tablets. Farmatsiya = Pharmacy 2019;68(2):17–23. (In Russ.).
  3. Solov’yova N.L., Sokurenko M.S. Medicinal chewing gum as a promising drug delivery system (review). Razrabotka i registratciya lekarstvennykh sredstv = Drug Development & Registration 2017;2:90–5. (In Russ.).
  4. Al Hagbani T., Nazzal S. Medicated chewing gums (MCGs): composition, production, and mechanical testing. AAPS PharmSciTech 2018;19(7):2908–20. doi: 10.1208/s12249-018-1123-z.
  5. Aslani A., Rostami F. Medicated chewing gum, a novel drug delivery system. J Res Med Sci 2015;20(4):403–11.
  6. Athanikar N.K., Gubler S.A. Process for manufacturing a pharmaceutical chewing gum. US Patent No 6322828, 2001.
  7. Chaudhary S.A., Shahiwala A.F. Medicated chewing gum – a potential drug delivery system. Expert Opin Drug Deliv 2010;7(7):871–85. doi: 10.1517/17425247.2010.493554.
  8. Gaonkar A.G., Vasisht N., Khare A.R. et al. Microencapsulation in the food industry. A practical implementation guide. Waltham: Academic Press, 2014. P. 569.
  9. Guo X., Chang R.K., Hussain M.A. Ionexchange resins as drug delivery carriers. J Pharm Sci 2009;98(11):3886–902. doi: 10.1002/jps.21706.
  10. Hedges A.R. Industrial applications of cyclodextrins. Chem Rev 1998;98(5):2035–44. doi: 10.1021/cr970014w.
  11. Khatun S., Sutradhar K.B. Medicated chewing gum: An unconventional drug delivery system. Int Curr Pharm J 2012;1(4):86–91. doi: 10.3329/icpj.v1i4.10064.
  12. Konar N., Palabiyik I., Toker O.S. Sagdic O. Chewing gum: production, quality parameters and opportunities for delivering bioactive compounds. Trends Food Sci Technol 2016;55:29–38. doi: 10.1016/j.tifs.2016.07.003.
  13. Kraemer J., Gajendran J., Guillot A., Barakat A. Chewable Oral Drug Products. In vitro Drug Release Testing of Special Dosage Forms 2019;2:27–53. doi: 10.1002/9781118675748.ch2.
  14. Makwana A., Sameja K., Raval V. et al. Chewing gum: a modern approach to oral mucosal drug delivery. Int J Pharm Res Dev 2011;4:1–16.
  15. Murakami S. et al. Method for manufacture of chewing gums with sectional motif patterns. US Patent No 4855146, 1989.
  16. Pagare P.K., Satpute C.S., Jadhav V.M. et al. Medicated chewing gum: a novel drug delivery system. JAPS 2012;2(06):40–54. doi: 10.7324/JAPS.2012.2706.
  17. Rekhi G.S. Advances in solid dose oral drug delivery. ON Drug Delivery 2010;3:14–8.
  18. Shah K.R., Mehta T.A. Medicated chewing gum – a mobile oral drug delivery system. Int J Pharm Tech Res 2014;6(1):35–48.
  19. Surana A.S. Chewing gum: A friendly oral mucosal drug delivery system. Int J Pharm Sci Rev Res 2010;4(2):68–71.
  20. Zieschang L., Klein M., Jung N. et al. Formulation development of medicated chewing gum tablets by direct compression using the SeDeMDiagram-Expert-System. Eur J Pharm Biopharm 2019;144:68–78. doi: 10.1016/j.ejpb.2019.09.003.

Supplementary files

Supplementary Files
Action
1. JATS XML
Download

Copyright (c)


СМИ зарегистрировано Федеральной службой по надзору в сфере связи, информационных технологий и массовых коммуникаций (Роскомнадзор).
Регистрационный номер и дата принятия решения о регистрации СМИ: серия ПИ № ФС77-53039 от  04.03.2013.