Email this article RECONSTITUTION OF B-CELLS IMMUNITY AFTER ALLOGENEIC HEMATOPOIETIC STEM CELL TRANSPLANTATION
- Authors: Chulkova S.V.1,2, Subbotina N.N.3, Petrova G.D.1, Sidorova N.V.1, Kolbatskaya O.P.1, Tupitsyn N.N.1, Nurtazinа A.Y.4
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Affiliations:
- N.N. Blokhin National Medical Research Center of Oncology of the Ministry of Health of the Russian Federation
- N.I. Pirogov Russian National Research Medical University
- Clinical Hospital “MEDSI”
- Sechenov First Moscow State Medical University, Ministry of Health of Russia
- Issue: Vol 19, No 2 (2020)
- Pages: 22-30
- Section: REVIEWS
- Published: 17.06.2020
- URL: https://bioterapevt.abvpress.ru/jour/article/view/1200
- DOI: https://doi.org/10.17650/1726-9784-2019-19-2-22-30
- ID: 1200
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Abstract
The restoration of B-cell immunity is a key component of the success of allogeneic hematopoietic stem cell transplantation. In most cases, the restoration of B-lymphopoiesis is a slow and often incomplete process, which is accompanied by a decrease in the tolerance of the recipient to bacterial, viral, fungal pathogens. This process is influenced by a number of factors that determine its effectiveness and pace. It is important to restore not only the size of the B-cell population, but also their functional usefulness. The article provides an analysis of modern literature data on the significance of the restoration of B-cell immunity after allogeneic hematopoietic stem cell transplantation, a review of the main factors affecting the process of B-lymphopoiesis, and their prognostic component.
About the authors
S. V. Chulkova
N.N. Blokhin National Medical Research Center of Oncology of the Ministry of Health of the Russian Federation;N.I. Pirogov Russian National Research Medical University
Author for correspondence.
Email: chulkova@mail.ru
ORCID iD: 0000-0003-4412-5019
24 Kashirskoe Shosse, Moscow 115478
1 Ostrovitianov St., Moscow 117997
Russian FederationN. N. Subbotina
Clinical Hospital “MEDSI”5, 2 nd Botkinskiy Proezd, Moscow 125284 Russian Federation
G. D. Petrova
N.N. Blokhin National Medical Research Center of Oncology of the Ministry of Health of the Russian Federation24 Kashirskoe Shosse, Moscow 115478 Russian Federation
N. V. Sidorova
N.N. Blokhin National Medical Research Center of Oncology of the Ministry of Health of the Russian Federation
ORCID iD: 0000-0003-3797-5808
24 Kashirskoe Shosse, Moscow 115478 Russian Federation
O. P. Kolbatskaya
N.N. Blokhin National Medical Research Center of Oncology of the Ministry of Health of the Russian Federation
ORCID iD: 0000-0001-8493-9012
24 Kashirskoe Shosse, Moscow 115478 Russian Federation
N. N. Tupitsyn
N.N. Blokhin National Medical Research Center of Oncology of the Ministry of Health of the Russian Federation
ORCID iD: 0000-0003-3966-128X
24 Kashirskoe Shosse, Moscow 115478
Russian Federation
A. Yu. Nurtazinа
Sechenov First Moscow State Medical University, Ministry of Health of Russia
ORCID iD: 0000-0002-2337-3307
8 Build 2, Trubetskaya St., Moscow 119991 Russian Federation
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