Email this article BASIC DETERMINANTS OF MELANOMA STEM CELL
- Authors: Vartanian A.A.1, Oborotova M.V.1
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Affiliations:
- ФГБНУ «РОНЦ им. Н.Н. Блохина»
- Issue: Vol 14, No 2 (2015)
- Pages: 7-16
- Section: REVIEWS
- Published: 30.06.2015
- URL: https://bioterapevt.abvpress.ru/jour/article/view/12
- DOI: https://doi.org/10.17650/1726-9784-2015-14-2-7-16
- ID: 12
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Abstract
Melanoma is considered to be the deadliest form of skin cancer. For years it has been accepted that all melanoma cells in tumor are capable of tumor formation and each of them has the ability to initiate the metastasis. At present a stem cell theory of cancer has been developed, which purports that a subpopulation of self-renewing tumor cells is responsible for tumorogenesis, neoangiogenesis and stroma building. In this review we will discuss the basic determinants of melanoma stem cell and melanoma stem cell targeting implications.
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About the authors
A. A. Vartanian
ФГБНУ «РОНЦ им. Н.Н. Блохина»
Author for correspondence.
Email: zhivotov57@mail.ru
Russian Federation
M. V. Oborotova
ФГБНУ «РОНЦ им. Н.Н. Блохина»Russian Federation
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