DOPAMINERGIC SYSTEM: STRESS, DEPRESSION AND CANCER (PART 2)

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Abstract

In today’s world, we are constantly exposed to stress. At the same time, if acute stress can have a positive effect on the body, constant stress usually harms health, leading to serious diseases, including cancer, which is considered to be age-related disease. It is also known that stress can significantly deteriorate the efficacy of chemotherapies and anti-tumour immune response, promote tumor growth and metastasis spreading. Meanwhile dopamin known to be antiaging and antistress agent is able to inhibit tumourgenesis. Therefore the role of Central neuronal processes involving the dopaminergic system in the mechanisms of malignant growth control is discussed in the present review.

About the authors

O. A. Bocharova

N.N. Blokhin National Medical Research Center of Oncology of the Ministry of Health of the Russian Federation

Author for correspondence.
Email: imufarm@rambler.ru
ORCID iD: 0000-0002-6365-2888
24 Kashirskoye Shosse, Moscow 115478, Russia Russian Federation

E. V. Bocharov

N.N. Blokhin National Medical Research Center of Oncology of the Ministry of Health of the Russian Federation

ORCID iD: 0000-0003-2342-9881
24 Kashirskoye Shosse, Moscow 115478, Russia Russian Federation

V. G. Kucheryanu

Institute of general pathology and pathophysiology

ORCID iD: 0000-0002-5071-3581
8 Baltiyskaya St., Moscow 125315, Russia Russian Federation

R. V. Karpova

N.N. Blokhin National Medical Research Center of Oncology of the Ministry of Health of the Russian Federation

ORCID iD: 0000-0003-4893-1472
24 Kashirskoye Shosse, Moscow 115478, Russia Russian Federation

A. A. Vershinskaya

N.N. Blokhin National Medical Research Center of Oncology of the Ministry of Health of the Russian Federation

24 Kashirskoye Shosse, Moscow 115478, Russia

Russian Federation

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