Email this article The influence of multiphytoadaptogen on leukocyte infiltration in mice hepatocarcinomas
- Authors: Karpova R.V.1, Bocharov E.V.1, Bocharova O.A.1, Kazeev I.V.1, Kucheryanu V.G.2, Soloviev Y.N.1
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Affiliations:
- N.N. Blokhin National Medical Research Center of Oncology Ministry of Health of Russia.
- Institute of general pathology and pathophysiology.
- Issue: Vol 18, No 2 (2019)
- Pages: 60-65
- Section: ORIGINAL REPORTS
- Published: 15.06.2019
- URL: https://bioterapevt.abvpress.ru/jour/article/view/1157
- DOI: https://doi.org/10.17650/1726-9784-2019-18-2-60-65
- ID: 1157
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Abstract
The aim of this study was the morphological investigation of the CBA mice liver tissue at different stages of ontogenesis as well as during liquid form multifitoadaptogen therapeutic administration.
Materials and methods . The study objects are the liver samples of CBA male mice (subline CBA / LacY). Experimental animals received a 10 % solution of multifitoadaptogen from 6 months of age until natural death. Tissue samples were fixed in neutral buffered formalin and embedded in paraffin. Sections from paraffin blocks were stained with hematoxylin and eosin. The structure of the liver tumours was determined as well as the quantitаtive degree of leukocyte infiltration in the tumour tissue.
Results . The tumours morphologically structured as moderately differentiated trabecular hepatocarcinomas (at 8 months of age) and low differentiated trabecular-acinar hepatocarcinomas (aged 22 months) were revealed in CBA male mice. Higher lever of leukocyte infiltration in hepatocarcinomas of experimental animals was determined.
Conclusion . Leukocyte infiltration may be important for antitumour immune reaction as well as for reduction of the tumour formation incidence in high-cancer mice.
About the authors
R. V. Karpova
N.N. Blokhin National Medical Research Center of Oncology Ministry of Health of Russia.
Author for correspondence.
Email: planta39@rambler.ru
ORCID iD: 0000-0003-4893-1472
24 Kashirskoe Sh., Moscow 115478. Russian Federation
E. V. Bocharov
N.N. Blokhin National Medical Research Center of Oncology Ministry of Health of Russia.
ORCID iD: 0000-0003-2342-9881
24 Kashirskoe Sh., Moscow 115478. Russian Federation
O. A. Bocharova
N.N. Blokhin National Medical Research Center of Oncology Ministry of Health of Russia.
ORCID iD: 0000-0002-6365-2888
24 Kashirskoe Sh., Moscow 115478. Russian Federation
I. V. Kazeev
N.N. Blokhin National Medical Research Center of Oncology Ministry of Health of Russia.24 Kashirskoe Sh., Moscow 115478. Russian Federation
V. G. Kucheryanu
Institute of general pathology and pathophysiology.
ORCID iD: 0000-0002-5071-3581
8 Baltiyskaya St., Moscow 125315. Russian Federation
Yu. N. Soloviev
N.N. Blokhin National Medical Research Center of Oncology Ministry of Health of Russia.24 Kashirskoe Sh., Moscow 115478. Russian Federation
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